Patients with chronic kidney disease and end-stage renal disease are at 5- to 10-fold higher risk for developing cardiovascular disease (CVD) than age-matched controls. Clinically, CVD in this population manifests as coronary artery disease, arrhythmias, stroke, or congestive heart failure. Beyond the traditional risk factors (eg, diabetes mellitus and hypertension), uremia-specific factors tha...

15 cases of acute renal failure follow ing ingestion of bichloride of mercury were studied at pahlavi medical center, university of teheran, between 196? and 1972. all the patients admitted suicide attempts. all had oliguria and uremia except one, in whom oliguria was moderate without azotemia. there were four deaths among the 15 patients, tgastrointestinal hernorrage; secondery infection and t...

Pathophysiology of acute uremia Acute renal failure has traditionally been classified as Pre-renal, intrinsic renal, and/or Post-renal in origin. Careful scrutiny of history, physical examination, laboratory findings and imaging studies of cats presenting with signs of an acute uremic crisis usually provides adequate information to identify Pre-renal, renal and Post-renal components of uremia. ...

Neurological complications due to the uremic state or hemodialysis, contribute to the important cause of mortality in patients with uremia. Despite continuous advances in uremic treatment, many neurological complications of uremia, like uremic encephalopathy, peripheral neuropathy and myopathy fail to fully respond to hemodialysis. Moreover, hemodialysis or kidney transplantation may even induc...

Parathyroid hyperplasia, oversecretion of parathyroid hormone (PTH), and hyperparathyroid bone disease are characteristic features of chronic uremia; they develop early in the course of uremia and often in a progressive way. This review focuses on the potential for arrest or regression of hyperparathyroid-induced bone disease. For this purpose, the review addresses investigations that have used...

An organic compound that inhibits drug binding in uremia has been isolated from the sera of chronic renal failure patients, and its chemical structure has been determined. Addition of the compound to normal human sera in vitro resulted in drug binding defects similar to those seen in uremia. The purification of this substance was accomplished by n-butyl chloride extraction of acidified (pH 3.0)...

Resistance to insulin-mediated glucose uptake is well documented in uremia. We have previously reported that in vivo resistance to insulin mediated amino acid uptake is present in the skeletal muscle of acutely uremic rats. This report compares the effect of insulin on in vitro 14C alpha-amino isobutyric acid and cycloleucine uptake by skeletal muscle from uremic and control rats. Intracellular...