Cisplatin (cis-diamminedichloroplatinum II), as one of the most applicable and potent anticancer medication, is used in the treatment of a various pediatric and adult malignancies. However, it gives side-effects such as renal toxicity which is dose-dependent, and thus limited its usage. Treatment with cisplatin induces the inflammatory mechanisms, which leads to a reduction in the antioxidant l...

We describe the synthesis and biological evaluation of C-glycosyl chalcone analogues of aspalathin. The DPPH radical scavenging method was used to detect their antioxidant activity and an MTT colorimetric assay was employed to test the anticancer activity against Hep-G2 liver carcinoma cells and MCF-7 human breast carcinoma cells. The antioxidant ability between C-furanosides and C-pyranosides ...

The aim of this study was to evaluate concentration-dependent antioxidant and anticancer activities of CA and RA in ethanol extracts of three different Oregano species (Origanum onites L., Origanum vulgare L., and Origanum vulgare ssp. hirtum). The study revealed the highest RA antioxidant activity in O. vulgare ssp. hirtum (9550 ± 95 mmol/g) and the lowest in O. vulgare L. (2605 ± 52 mmol/g) (...

Respiratory system diseases are common and major ailments that seriously endanger human health. Resveratrol, a polyphenolic phytoalexin, is considered an anti-inflammatory, antioxidant, and anticancer agent. Thanks to its wide range of biological activities, resveratrol has become a hotspot in many fields, including respiratory system diseases. Indeed, research has demonstrated that resveratrol...

The present study aimed to evaluate Antioxidant and Cytotoxic activity of phytofabricated silver nanoparticles (FmF-AgNPs) derived from Figs Ficus mollis. This green synthesized FmF-AgNPs were tested for antioxidant with DPPH assay cytotoxicity against MCF-7 (Human breast adenocarcinoma cell lines) MTT at various concentrations. data obtained demonstrated that posses both which is dosage-depend...

In the past few decades, the incidence of liver cancer has been rapidly rising across the world. Rosemary is known to possess antioxidant activity and is used as natural antioxidant food preservative. It is proposed to have anticancer activity in treating different tumor models. In this study, we try to explore the impact of rosemary extracts on upregulating the level of Nrf2 and Nrf2-regulator...

BACKGROUND Acacia hydaspica R. Parker, family leguminosae, is a medicinally important plant. Different plant parts are used in various ailments in folk medicine. The current study aimed at investigating the in vitro antioxidant, anti-hemolytic and anticancer activity of A. hydaspica. METHODS Antioxidant potential was assessed using DPPH, ABTS and •OH, scavenging of H2O2, inhibition of lipid p...

Introduction: Cancer is a non-communicable disease with over 18.1 million new cases and 9.6 deaths annually according to WHO. Breast cancer the number two highest count type of trailing behind lung cancer. Treating expensive have various side effects. Active components found in plants or fungi that antioxidant cytotoxic activity towards cells, could be an alternative for anticancer. One potenti...

Heterocyclic compounds are an important class of in the field pharmaceutical and synthetic organic chemistry. The Schiff bases contain azomethine linkages which obtained by condensation aldehyde/ketone with amines. Among various types bases, chalcone-based play a vital role treatment ailments applications, can be synthesized using different chalcones as starting materials. These were techniques...

The objective of this research was to study the pharmacology of Dioscorea bulbifera L. on antioxidant and anticancer activity. Alcohol extracts of Dioscorea bulbifera L. were made out by different concentration alcohol; they were tested by Hydroxyl radical scavenging test, reducing capacity test and total antioxidant capacity test. In the anticancer test, MTT test was used to study the inhibiti...