ginger (zingiber officinale roscoe) contains the biological properties of the major standard non–volatile pungent compounds of ginger, namely, [6]–, [8]–, and [10]–gingerols, as well as [6]– , [8]–, and [10]–shogaols. so far, the comparative antioxidant potencies among shogaols and gingerols have not been studied in detail and reported. accordingly, this study aimed to examine and compare the a...

Vascular diseases are the most prominent cause of death, and inflammation and vascular dysfunction are key initiators of the pathophysiology of vascular disease. Lipid peroxidation products, such as acrolein and other α, β-unsaturated aldehydes, have been implicated as mediators of inflammation and vascular dysfunction. α, β-Unsaturated aldehydes are toxic because of their high reactivity with ...

Pironetin is a natural product with potent antiproliferative activity that forms a covalent adduct with α-tubulin via conjugate addition into the natural product's α,β-unsaturated lactone. Although pironetin's α,β-unsaturated lactone is involved in its binding to tubulin, the structure-activity relationship at different positions of the lactone have not been thoroughly evaluated. For a systemat...

Visible-light photoredox catalysis has been utilized in a new multicomponent reaction forming β-functionalized δ-diketones under mild conditions in an operationally convenient manner. Single-electron reduction of in situ generated carboxylic acid derivatives forms acyl radicals that react further via 1,2-acylalkylation of olefins in an intermolecular, three-components cascade reaction, giving v...

New series of 2,3-disubstituted quinazolin-4(3H)one were synthesized via the reaction of the readily obtainable 2-thioxo-3-phenyl-quinazolin-4(3H)one 1 with ethyl chloroacetate followed by hydrazinolysis to afford the hydrazide 3 which allowed to react with different electrophilic reagents such as carbon disulphide, phenyl isothiocyanate, β-diketones, anhydrides, acrylonitrile, ethyl cinnamate,...

In photoinduced molecular reaction dynamics, the effects of electronic charge redistribution can lead to multiple pathways that are determined by the nature of the initial structures involved and the environment the molecule of interest is studied in. The β-diketones are a common example of this complexity. They show keto-enol tautomerism that is almost totally shifted toward the enolic form. H...

Four Schiff bases (H2L1 to H2L4) were synthesized by the condensation of o-aminophenol and unsaturated diketones (1,5-diarylpent-4-ene-1,3- -diones). Analytical, IR, 1H-NMR mass spectral data revealed their existence in imine?enamine form. Dibasic tetradentate coordination ML complexes (M = Cu(II), Ni(II), Co(II), Zn(II), Cd(II), Hg(II)) was established based on physical, analytical data. The f...

Nitroolefins are usually synthesized using the Henry reaction. Here we report an alternative metal-free decarboxylative nitration protocol for the preparation of the nitroolefins from α,β-unsaturated carboxylic acids using t-butylnitrite (t-BuONO) and TEMPO. α,β-Unsaturated carboxylic acids bearing β-aromatic and β-heteroaromatic substituents gave (E)-nitroolefins exclusively under mild conditi...