In addition to studies concerning the regulation of enzyme activity and synthesis in minimal deviation hepatomas (10, 15, 16), it is of interest to investigate how the production and secre tion of serum proteins is affected by the change of normal liver to a minimal deviation hepatoma. Morphologic studies of the ultrastructure of the tumor cell (especially of the endoplasmic reticulum-Golgi app...

Price and his associates (17, 18, 19) found al terations in the amounts of protein, nucleic acids, and riboflavin in various fractions of the liver during the induction of liver tumors by a series of aminoazo dyes of widely different carcinogenic ac tivities. The changes induced by the more active carcinogens made the composition of the liver ap proach that of the tumors induced by the parent c...

Synchronization is the process of achieving identical dynamics among coupled identical units. If the units are different from each other, their dynamics cannot become identical; yet, after transients, there may emerge a functional relationship between them-a phenomenon termed "generalized synchronization." Here, we show that the concept of transient uncoupling, recently introduced for synchroni...

OBJECTIVE Gastric cancer (GC) is widely associated with chronic inflammation. The pro inflammatory microenvironment provides conditions that disrupt stem/progenitor cell proliferation and differentiation. The signal transducer and activator of transcrip- tion-3 (STAT3) signaling pathway is involved in inflammation and also contributes to the maintenance of embryonic stem cell (ESCs) pluripotenc...

The feline oncornavirus associated cell membrane antigen (FOCMA) is expressed on the membranes of cells transformed by infection with the feline leukemia virus (FOCMA-L) or feline sarcoma virus (FOCMA-S) (Hardy et al. 1977; Essex et al. 1977). Expression of FOCMA is transformation-specific and not dependent upon concomitant expression of antigens associated with feline leukemia virus (FeLV) or ...

The problem of nding the naturally occurring structure of a pro tein is believed to correspond to minimizing the free or potential energy of the protein This is generally a very di cult global optimizationproblem with a large number of parameters and a huge number of local minimizers includ ing many with function values near that of the global minimizer This paper presents a new global optimiza...

studies, we investigated the effects of: (a) a single feeding of a complete mixture of amino acids on individual amino acids to fasted animals (21 , 24, 27); (b) a single feeding of a purified diet devoid of protein on amino acids (23); (c) force feeding a purified diet devoid of single essential amino acids for 1 to 3 days (16). Under these experimental conditions, hepatic pro tein synthesis w...

azo dyes in the rat revealed an increase in DNA and a decrease in RNA per gm tissue in precancerous liver and hepatoma (11, 12), although occasional inconsistencies were observed. Recent studies (9) in which RNA and DNA were isolated and purified have confirmed the de crease in total RNA relative to DNA. In these studies O'Sullivan (9) found no significant alteration in nucleotide base composit...

One of the major effects of the presence of a neoplasm on the host is a disturbance of the pro tein metabolism (8,13). Efforts have been made to take advantage of this for diagnostic purposes by determining some particular change in the con tent or the properties of the plasma proteins (1, 6, 7). These efforts have had a very limited success, because it was found that the observed effects did n...