CFTR is a transmembrane protein that reaches the cell surface via the conventional Golgi mediated secretion pathway. Interestingly, ER-to-Golgi blockade or ER stress induces alternative GRASP-mediated, Golgi-bypassing unconventional trafficking of wild-type CFTR and the disease-causing ΔF508-CFTR, which has folding and trafficking defects. Here, we show that Sec16A, the key regulator of convent...

In the paper I sketch a theory of massively parallel proofs using cellular automata presentation of deduction. In this presentation inference rules play the role of cellular-automatic local transition functions. In this approach we completely avoid axioms as necessary notion of deduction theory and therefore we can use cyclic proofs without additional problems. As a result, a theory of massive-...

*Correspondence: Christof Teuscher , Department of Electrical and Computer Engineering, Portland State University, 1900 SW 4th Avenue, Portland, OR 97206, USA e-mail: [email protected] What makes a new paradigm or technology promising? What should science, research, and industry invest money in? Is there a life after CMOS electronics? And will the vacuum tube be back? While one cannot predict th...

The field of computer music is evolving in tandem with advances in computer science. Our research is interested in how the developing field of unconventional computation may provide new pathways for music and music technologies. In this paper we present the development of a system for harnessing the biological computing substrate Physarum Polycephalum for sonification. Physarum Polycephalum is ...

How do aggregate quantities at the business cycle frequency respond to shocks to the spread between residential mortgage rates and government bonds? Using a structural VAR approach, we find that mortgage spread shocks impact the real economy by both economically and statistically significant magnitudes: a 100 basis point decline in the spread causes a peak increase in consumption, residential i...

An extensive intraoral maxillofacial prosthesis presents challenges to the clinician in many ways. The problems encountered include that of support and retention of the prosthesis. These problems arise due to unfavorable anatomical configuration of the defect. This unfavorable configuration may prompt the clinician to device alternate /additional means of support and retention. The aim of this ...

This report provides an overview of the current state of the art deep learning architectures and optimisation techniques, and uses the ADNI hippocampus MRI dataset as an example to compare the effectiveness and efficiency of different convolutional architectures on the task of patch-based 3dimensional hippocampal segmentation, which is important in the diagnosis of Alzheimer’s Disease. We found...

This paper introduces BioComputer Music, an experimental one-piano duet between pianist and plasmodial slime mould Physarum polycephalum. This piece harnesses a system we have been developing, which we call BioComputer. BioComputer consists of an analogue circuit that encompasses components grown from the biological computing substrate Physarum polycephalum. Our system listens to the pianist an...

Physics imposes some limits to the computations that we can perform. Because of these limits we cannot solve problems in almost no time and with almost zero energy consumption. The main problem is that we are asking too much from a single device: we want computers that play chess, solve equations, navigate on the internet etc. Because of this great generality we are paying some big prices (in t...