BACKGROUND The vacuolating cytotoxin and the cytotoxinassociated protein, encoded by vacA and cagA, respectively, are important virulence determinants of Helicobacter pylori. OBJECTIVE The aim of this study was to perform vacA genotyping and evaluate its association with cagA genotype and clinical outcome. METHODS One hundred and twenty H. pylori strains were isolated from dyspeptic patient...

Functional dyspepsia in children is classified as a subset of functional pediatric gastrointestinal disorders. According to ROME II criteria, it is divided into 3 groups including ulcer-like dyspepsia, dysmotility-like dyspepsia and unspecified (non-specific) dyspepsia. Prevalence of functional dyspepsia had been reported around 3/5 of children and adolescents who presented with clinical dyspep...

Therapeutic effect of cimetidine in non ulcer dyspepsia was studied in a placebo controlled trial. The reduction of pain was statistically significant in both groups during the first week of treatment but no change in subsequent three weeks. It was concluded that cimetidine has no therapeutic advantage over the placebo in dyspeptic patients (JPMA 38: 168,1988). INTRODUCTION Non ulcer dyspepsia ...

background: regulatory t cells (tregs) and myeloid-derived suppressor cells (mdscs) are two main regulatory cells modulating the immune responses in inflammation and cancer. objective: to investigate and compare tregs and mdscs in peptic ulcer and gastric cancer. methods: patients with dyspepsia were selected and divided into three groups of non-ulcer dyspepsia (nud, n=22), peptic ulcer disease...

This study aims to determine whether the features of dyspepsia can discriminate a subgroup of patients who present with non-ulcer dyspepsia from other diagnostic categories. The following groups were studied: One hundred and thirteen patients with endoscopically confirmed non-ulcer dyspepsia in the absence of clinical, biochemical or radiological evidence of other gastrointestinal diseases or d...

BACKGROUND Helicobacter pylori eradication therapy is routinely used for treating patients with peptic ulcer disease. AIMS To assess the value of symptomatic response to H pylori eradication therapy as a marker of post-treatment H pylori status. PATIENTS AND METHODS One hundred and nine dyspeptic patients with active duodenal or gastric ulceration association with H pylori infection had the...

The role of fibreoptic upper gastrointestinal endoscopy as the primary investigation in Malaysians presenting with dyspepsia was studied in 1119 patients. Five hundred and sixty-two of the examinations (50 percent) were normal. Females below 40 years of age were very likely to have normal endoscopies. Peptic ulcer was seen in 21 percent of patients while visual evidence of gastric or duodenal m...

background :   vaculating cytotoxic a ( vaca ) gene is one of the multiple helicobacter pylori genotypes that produce a cytotoxin protein (vaca).this gene is a major cause of chronic peptic ulcers and gastric cancer. the aim of this study was to determine the correlation between vaca gene with peptic ulcer disease (pud) and non-ulcer dyspepsia (nud). methods :    this was a case control study o...