نتایج جستجو برای: tyrode

تعداد نتایج: 296  

1999
JOHN P. GAUGHAN SATOSHI FURUKAWA VALLUVAN JEEVANANDAM COLLEEN A. HEFNER HAJIME KUBO KENNETH B. MARGULIES BRIAN S. MCGOWAN JULIAN A. MATTIELLO KONSTANTINA DIPLA VALENTINO PIACENTINO SIYUN LI STEVEN R. HOUSER Colleen A. Hefner Hajime Kubo Kenneth B. Margulies Brian S. McGowan Julian A. Mattiello Siyun Li

Gaughan, John P., Satoshi Furukawa, Valluvan Jeevanandam, Colleen A. Hefner, Hajime Kubo, Kenneth B. Margulies, Brian S. McGowan, Julian A. Mattiello, Konstantina Dipla, Valentino Piacentino III, Siyun Li, and Steven R. Houser. Sodium/calcium exchange contributes to contraction and relaxation in failed human ventricular myocytes. Am. J. Physiol. 277 (Heart Circ. Physiol. 46): H714–H724, 1999.—D...

Journal: :Circulation 2011
Angela D Sellitto Ashraf S Al-Dadah Richard B Schuessler Colin G Nichols Jennifer S Lawton

BACKGROUND Stress (exposure to hyperkalemic cardioplegia, metabolic inhibition, or osmotic) results in significant myocyte swelling and reduced contractility. In contrast to wild-type mice, these detrimental consequences are not observed in mice lacking the Kir6.2 subunit of the sarcolemmal ATP-sensitive potassium (sK(ATP)) channel after exposure to hyperkalemic cardioplegia. The hypothesis for...

2014
Massimiliano Zaniboni Francesca Cacciani Robert L. Lux

The heartbeat arises rhythmically in the sino-atrial node (SAN) and then spreads regularly throughout the heart. The molecular mechanism underlying SAN rhythm has been attributed by recent studies to the interplay between two clocks, one involving the hyperpolarization activated cation current If (the membrane clock), and the second attributable to activation of the electrogenic NaCa exchanger ...

Journal: :American journal of physiology. Heart and circulatory physiology 2003
You-Wen Qian Ruey J Sung Shien-Fong Lin Rose Province William T Clusin

Cardiac ischemia causes beat-to-beat fluctuation in action potential duration (APD) alternans, which leads to T wave alternans and arrhythmias. Occurrence of APD alternans that is out of phase at two sites is especially important, but most APD alternans studies have involved rapid pacing of normal myocardium rather than ischemia. To determine the spatial features of APD alternans during ischemi...

Journal: :Physiological research 2006
Y Wondmikun T Soukup G Asmussen

The slow-twitch soleus muscle (SOL) exhibits decreased twitch tension (cold depression) in response to a decreased temperature, whereas the fast-twitch extensor digitorum longus (EDL) muscle shows enhanced twitch tension (cold potentiation). On the other hand, the slow-twitch SOL muscle is more sensitive to twitch potentiation and contractures evoked by caffeine than the fast-twitch EDL muscle....

Journal: :The Journal of General Physiology 1937
Henry S. Simms Nettie P. Stillman

1. The growth of fresh adult tissue in plasma medium suggested that plasma contained a substance active in overcoming the dormancy of adult tissues. 2. Incubation of adult chicken aorta in serum (from chickens or other species) before it was planted in a plasma medium, resulted in a much shorter lag period and a faster initial growth than that of control tissue incubated in Tyrode solution (or ...

Journal: :Journal of the American College of Cardiology 1999
M Flesch H Kilter B Cremers U Laufs M Südkamp M Ortmann F U Müller M Böhm

OBJECTIVES This study examined the effects of endotoxin on cardiac contractility in human myocardium. BACKGROUND In animal myocardium, endotoxin and cytokine treatment led to enhanced inducible nitric oxide synthase (iNOS) expression and contractile dysfunction. Effects in human myocardium are unknown. METHODS Left ventricular myocardial preparations from failing (n = 18) and nonfailing (n ...

Journal: :The Journal of pharmacology and experimental therapeutics 1997
P Daleau M Khalifa J Turgeon

Block of the slow inward calcium current (Isi) during assessment of the delayed rectifier potassium current (IK) of cardiac ventricular myocytes is commonly achieved by use of either inorganic compounds such as cadmium or dihydropyridine derivatives such as nisoldipine. Effects of these two Isi blockers on IK characteristics of guinea pig ventricular myocytes were compared in this study. Curren...

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