Melanotic Neuroectodermal Tumour of Infancy (MNTI) is a rare neoplasm typically reported in infancy, involving the head and neck regions. Although described as benign tumour, growth rapid has high local recurrence rate. Due to locally destructive growth, it can easily be misdiagnosed malignant leading unwarranted potentially harmful interventions. Therefore, histopathological assessment pertine...

Macrophages’ role in the evolution of solid tumours is a well accepted fact, with M1-like macrophages having an anti-tumour and M2-like pro-tumour role. Despite fact that some clinical studies on lung have emphasised also presence mixed M1 M2 phenotypes addition to distinct phenotypes, majority still use M1-M2 classification predict patient survival. In this theoretical study we mathematical mo...

The success of oncolytic virotherapies depends on the tumour microenvironment, which contains a large number infiltrating immune cells. In this theoretical study, we derive an ODE model to investigate interactions between breast cancer cells, virus (Vesicular Stomatitis Virus), and tumour-infiltrating macrophages with different phenotypes can impact dynamics viruses. complexity requires combine...

Immune checkpoint inhibitors or anti-cancer immunotherapy using cellular transfer have emerged as new therapies in this field. These work to overcome alleviate tumour-induced immunosuppression, resulting immune-mediated tumour clearance. Cellular the largest number of active agents and clinical trials. More targets been explored, more trials opened patients recruited for a result recent advance...

Background: Over-expression of CD117 and cytokeratin 20 (CK20) is seen in many malignancies. Given that few studies have been conducted regarding the role of these biomarkers in the etiology of bladder tumours, this study aimed to evaluate the prognostic value of CD117 and CK 20 biomarkers in the benign and malignant tumours of urinary bladder carcinoma. Methods: This case-control study was co...