Tumor cells are surrounded by infiltrating inflammatory cells, such as lymphocytes, neutrophils, macrophages, and mast cells. A body of evidence indicates that mast cells are associated with various types of tumors. Although role of mast cells can be directly related to their granule content, their function in angiogenesis and tumor progression remains obscure. This study aims to understand the...

background: invasive ductal carcinoma is the most common type of breast cancer in iran. impaired immune responses occur frequently in cancer patients, but the mechanisms of the induced immune defects remain poorly understood. it is believed that infiltrated immune cells, especially macrophages, may provide help for tumor cell growth and metastasis.   objective: to analyze the status of tumor as...

Next-generation sequencing (NGS) and digital PCR technologies allow analysis of the mutational profile of circulating cell-free DNA (cfDNA) in individuals with advanced lung cancer. We have now evaluated the feasibility of cfDNA sequencing for mutation detection in patients with non-small cell lung cancer at earlier stages. A total of 150 matched tumor and serum samples were collected from non-...

Breast cancer is the most common invasive cancer in women worldwide. Metalloproteinases MMP2 and MMP9 participate in tumor invasion and metastasis by degrading extracellular matrix. In this study, we investigated the expression of MMP2 and MMP9 in breast tissues of Iraqi women with stage II and III breast cancer. The correlation between the expression levels of MMP2 and MMP9 in stage II-III bre...

As tumor cells metastasize from the primary tumor location to a distant secondary site, they encounter an array of biologically and physically heterogeneous microenvironments. While it is well established that biochemical signals guide all stages of the metastatic cascade, mounting evidence indicates that physical cues also direct tumor cell behavior, including adhesion and migration phenotypes...

In this study, we demonstrate a method for controlling breast cancer cells adhesion on polyelectrolyte multilayer (PEM) films without the aid of adhesive proteins/ligands to study the role of tumor and stromal cell interaction on cancer biology. Numerous studies have explored engineering coculture of tumor and stromal cells predominantly using transwell coculture of stromal cells cultured onto ...

Transition patterns between different sleep stages are analysed in terms of probability distributions of symbolic sequences for young and old subjects with and without sleep disorder. Changes of these patterns due to ageing are compared with variations of transition probabilities due to sleep disorder.

The study's purpose was to identify the mediating role of intention and the stages of change (SOC) in physical activity (PA) over a 6-month period using two models (theory of planned behavior [TPB] and TPB/SOC). Participants were 143 adults with physical disabilities (70.68% response rate; M age = 46.03). The TPB constructs, SOC (time 1), and PA (time 2) were assessed using standardized self-re...

Cholangioblastic variant of intrahepatic cholangiocarcinoma is a rare, extremely malignant liver tumor. Currently, only six clinical cases have been described worldwide. Following the bibliographic research, authors paper introduced main features tumor, methods its diagnosis and treatment. A observation patient with cholangioblastic presented. The course disease was complicated by tumor thrombo...