Background The pro-inflammatory cytokine, tumor necrosis factor-alpha (TNF-α), is a pathogenic element for a number of disorders. Previous studies have reported that the -1031 T/C and -238 G/A polymorphisms in the promoter region of the TNF-α gene are important factors in reproductive-related disorders. One of the most common gynecological diseases of women during the reproductive years is endo...

Introduction: 99mTc-MIBI has been proposed for use as an imaging agent for various tumors, including breast cancer, lung cancer, lymphomas, melanomas and brain neoplastic lesions. Brain tumors are very common and radiotherapy being major part of treatment following surgery. After radiotherapy, deteriorating clinical status can be due to either radiation necrosis or recurrent tumor. Comput...

objectives: multidrug resistance (mdr), which may be due to the over expression of p-glycoprotein (pgp) and/or mrp, is a major problem in neoadjuvant chemotherapy of osteosarcoma. the aim of this study was to investigate the role of tc-99m mibi scan for predicting the response to pre-operative chemotherapy. materials and methods: twenty-five patients (12 males and 13 females, aged between 8 and...

objective(s): acquisition of tnf-α resistance plays role in the onset and growth of malignant tumors. previous studies have demonstrated that mcf-7 cell line and its doxorubicin resistant variant mcf-7/adr are resistant against the cytotoxic effects of tnf-α. in this study, we investigated the role of akt activation in resistance of mcf-7 and mcf-7/adr against tnf-α cytotoxicity. materials and ...

cytokines play a part in pathogenesis of periodontitis via inflammation phenomenon. aggressive periodontitis (agp) is a multifactorial disease resulting in rapid tooth loss due to severe destruction of tooth supporting apparatus. recently, researchers have focused on genetic susceptibility of periodontitis through investigating the gene variations of cytokines and other components of immune res...

objective(s) using herbal medicines as a complementary treatment method is increasing in wide variety of diseases. ms14-an herbal-marine preparation-is reported to have anti-inflammatory and immunomodulatory activities; however, the mechanism underlying its therapeutic effect is not known. macrophages play an important role in host defense mechanisms and carry out their role by producing variou...

spinal cord injury (sci) is a crucial complication that results in neurons degeneration. the sci lead to triggering of secondary complications such as inflammation that in turn has a key role in neurodegeneration development. the previous studies showed that tnf-α and inos genes expression increased significantly after sci. as a consequence, these genes overexpression intensify the inflammation...

The protective effect of B vitamins combination against zinc oxid bulk (ZnO-bulk) and its nanparticles (ZnO-NPs) toxicity -induced kidney damage in rats was investigated. ZnObulk or its NPs were administered orally (500 mg /kg body weight) for 10 consecutive days. The results revealed that oral co-ingestion of of B vitamins combination (250 mg B3, 60 mg B6 and 0.6 mg B12 / Kg body weight) daily...