نتایج جستجو برای: tumor cell lysate
تعداد نتایج: 1918054 فیلتر نتایج به سال:
Dendritic cells (DCs) have been used successfully for inducing effective anti-tumor immune responses in advanced cancer patients undergoing tumor-specific immunotherapy. Appropriate antigen pulsing is a crucial parameter for optimizing the efficacy of immunotherapy as well as anti-tumor protection therapy. Using a murine colon cancer model, we evaluated the anti-tumor efficacy of four different...
objective: dendritic cells (dcs) play a critical role in the beginning and in the course of immune responses. by observing. considering the defect in these cells in patients with tumor malignancy. in recent years there has been considerable interests in correction and use of these cells. in our prvious studies we showed that lysate of listeria monocytogenese can induce maturation of dendritic c...
Melanin is capable of transforming 99.9% of the absorbed sunlight energy into heat, reducing the risk of skin cancer. We here develop a melanin-mediated cancer immunotherapy strategy through a transdermal microneedle patch. B16F10 whole tumor lysate containing melanin is loaded into polymeric microneedles that allow sustained release of the lysate upon insertion into the skin. In combination wi...
Abstract BACKGROUND The application of DC-CIK in the field cancer immunotherapy has been shown to be an effective treatment. However, cost treatment is prohibitive for many patients, and lack standard manufacturing processes strategies are main limitations. METHODS Our experiments used tumor lysate instead cell line as tumor-associated antigen source with DCs co-culture. We provide most efficie...
Methods Autologous mature dendritic cells (mDC) were manufactured from leukapheresed cells of NHL patients. For patients with tumor lymph nodes deemed amenable to cryoablation by interventional radiologist (arm A), they received cryoablation of a node and injection of mDC into the cryoablated node followed by another 1 to 7 intratumoral mDC injections. Remaining patients had a tumor excised to ...
RATIONALE We demonstrated previously that autologous tumor lysate-pulsed dendritic cell-based immunotherapy in patients with malignant pleural mesothelioma is feasible, well-tolerated, and capable of inducing immunologic responses against tumor cells. In our murine model, we found that reduction of regulatory T cells with metronomic cyclophosphamide increased the efficacy of immunotherapy. OB...
Human platelet lysate was shown to contain growth-promoting activity for four well-established malignant cell lines. Platelet lysate was able to support their cell proliferation without plasma or serum, indicating that platelets contained "survival factor" as well as mitogenic factor for these tumor cells. The growth-promoting activity was nondialyzable, heat stable up to 56 degrees, and partia...
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