OBJECTIVES Tumor-associated macrophages have been implicated in promoting tumor growth, progression and metastasis. However, the activated phenotype (M1 or M2) of tumor-associated macrophages remains unknown in solid tumors. Therefore, this study examined the density and prognostic significance of M2-polarized tumor-associated macrophages in lung adenocarcinoma. METHODS Tumor specimens from 6...

Abstract Macrophages are critical mediators of tissue homeostasis, cell proliferation, and tumor metastasis. Tumor-associated macrophages (TAM) generally associated with tumor-promoting immunosuppressive functions in solid tumors. Here, we examined the transcriptional landscape adaptor molecules downstream Toll-like receptors human cancers found that higher expression MYD88 correlated progressi...

Tumor-associated macrophages (TAMs) exist in nearly all tumors, and form a major part of the tumor microenvironment . TAMs are divided into two groups: tumor-suppressing M1 type tumor-promoting M2 type. Most educated by cells to become type, which support growth make immunotherapy ineffective. Antibody-dependent cellular phagocytosis (ADCP) is an important mechanism for antibody cancer therapy,...

Background and objectives The relationship between the tumor microenvironment network of key signaling pathways in cancer plays a role occurrence development tumors. Tumor-associated macrophages (TAMs) are important inflammatory cells play an tumorigenesis progression. Macrophages malignant tumors, mainly M2 subtype, promote progression by producing cytokines down-regulating anti-inflammatory i...

RAB42, member rat sarcoma oncogene family was proved to play a key role in cancer-promoting progression. However, its function the progression of bladder cancer still uncertain. We explored and pan-cancer using bioinformatics analysis, including expression, prognostic, genetic alteration, functional pathways, tumor microenvironment drug resistance. Our results indicated that expression increase...

Tumor-associated macrophages are able to regulate the tumor cell proliferation and affect dissemination. The study was aimed assess predictive potential of macrophage population immunohistochemical phenotyping in early malignization H. pylori-associated chronic gastritis. Gastic biopsy samples male female patients aged 48 ± 7.2 infected with Helicobacter pylori were used as research material. d...