Previous reports have established that line 1, a spontaneous BALB/c lung carcinoma, expresses a M, 180,000 tumor-associ ated surface antigen (TSP-180). In this study, using a monoclonal antibody and flow cytometry to quantify cell surface TSP-180 expression, we found that essentially all cells in a tissue cultureadapted line 1 population express TSP-180, but that the amount of TSP-180 expressed...

background: human t cell lymphotropic virus type i (htlv-i)-associated myelopa-thy/tropical spastic paraparesis (ham/tsp) is an inflammatory disease which occurs in less than 2% of htlv-i -infected individuals. high proviral load, high htlv-i-specific cd8+ cytotoxic t lymphocyte frequency (ctl) and host genetic factors such as hla all appear to be associated with htlv-i infection. previous stud...

In the Traveling Salesman Problem (TSP), a salesman wants to visit set of cities and return home. There is cost $$c_{ij}$$ traveling from city i j, which same in either direction for Symmetric TSP. The objective each exactly once, minimizing total travel costs. Graphical TSP, may be visited more than necessary on sparse graph. We present new integer programming formulation TSP requiring only tw...

Thrombospondin-1 (TSP-1), a matricellular protein and one of the first endogenous anti-angiogenic molecules identified, has long been considered a potent modulator of human diseases. While the therapeutic effect of TSP-1 to suppress cancer was investigated in both research and clinical settings, the mechanisms of how TSP-1 is regulated in cancer remain elusive, and the scientific answers to the...

Thrombospondin (TSP) contains the Arg-Gly-Asp (RGD) sequence that is thought to be important for cell adhesion mediated by several cell-surface integrin receptors. The RGD sequence is located in the type 3 repeat region of TSP that has multiple Ca2+ binding sites and is subject to a complex intramolecular thiol-disulfide isomerization. TSP that we isolated from thrombin-activated human platelet...

Desmoplastic (scirrhous) invasion and lymph node metastasis are critical for the treatment and prognosis of invasive ductal carcinoma of the breast. Despite being an anti-angiogenic therapeutic candidate, Thrombospondin-1 (TSP-1) promotes invasion and metastasis of some carcinomas. To clarify the effect of TSP-1 on invasion and metastasis, we obtained 101 invasive ductal carcinomas of the breas...

In this work, we study two special cases of the metric Travelling Salesman Problem, Graph TSP and TSP(1,2). At rst, we show that dense instances of TSP(1,2) and Graph TSP are essentially as hard to approximate as general instances of TSP(1,2). Next, we present an NC algorithm for TSP(1,2) that produces a tour of length at most n plus the cardinality of the Maximum Independent Set of the input g...

Thrombospondin (TSP) is a trimeric molecule synthesized by a variety of normal and transformed cells and secreted into the extracellular matrix. A number of studies have shown TSP to be intimately involved in the regulation of cellular proliferation. These include the findings that TSP is a mitogen-inducible immediate-early response gene; it localizes to areas of cellular proliferation in the d...

Thrombospondin-1 (TSP-1) is a multifunctional protein which is secreted into the extracellular matrix during inflammation, where it modulates numerous components of the immune infiltrate. Macrophages are a source of TSP-1, which they produce in response to TLR4 mediated signals. Their production of TSP-1 is regulated by environmental signals that establish a threshold for the level of protein s...

Pancreatic islet endothelial cells have in recent years been shown to support beta-cell mass and function by paracrine interactions. Recently, we identified an islets endothelial-specific glycoprotein, thrombospondin-1 (TSP-1), that showed to be of importance for islet angiogenesis and beta-cell function in young mice. The present study aimed to investigate long-term consequences for islet morp...