Polymorphisms in the untranslated regions (UTRs) of the thymidylate synthase (TS) gene, which may modulate TS transcription and expression, have been associated with susceptibility and prognosis of several tumors. However, their effects on the development and clinical staging of esophageal squamous cell carcinoma (ESCC) and gastric cardiac adenocarcinoma (GCA) have not been assessed so far. In ...

Trypanosoma cruzi the agent of Chagas disease is a monophyletic but heterogeneous group conformed by several Discrete Typing Units (DTUs) named TcI to TcVI characterized by genetic markers. The trans-sialidase (TS) is a virulence factor involved in cell invasion and pathogenesis that is differentially expressed in aggressive and less virulent parasite stocks. Genes encoding TS-related proteins ...

In this paper, we introduce a Takagi-Sugeno (TS) fuzzy model which is derived from a typical Multi-Layer Perceptron Neural Network (MLP NN). At first, it is shown that the considered MLP NN can be interpreted as a variety of TS fuzzy model. It is discussed that the utilized Membership Function (MF) in such TS fuzzy model, despite its flexible structure, has some major restrictions. After modify...

Significant advances have been made in the treatment of advanced colorectal cancer. At present, there are four main active drugs to treat the disease, and they include the fluoropyrimidines, 5-fluorouracil (5-FU) and capecitabine, irinotecan, and oxaliplatin. Over the past few years, intense research efforts have focused on developing molecular biomarkers that could predict response to these va...

The objective of this study was to estimate the heritability of 3 measures of temperament in Brahman and Brahman-influenced calves (n = 1,209). Individual animal pen scores (PS) were determined by a trained observer who evaluated groups of 5 or 4 calves at a time for willingness to be approached by a human. Exit velocity (EV) was the rate (m/s) at which each calf exited a squeeze chute. Tempera...

Milk samples from 28 cows were analysed for residues of oxacillin after drying off with Stapenor Retard TS (oxacillin). Analysis was performed with an automated HPLC system consisting of an on-line solid-phase extraction and photochemical post-column derivatization with UV-detection at 300 nm. Although the time interval between treatment and parturition was less than the demanded 55 days, the m...

New models for education dissemination have emerged with the growth of distributed systems, especially with the widespread penetration of Internet. This has made possible imparting education on a larger scale. Distance evaluation of students constitutes a crucial factor for success of Distance Education initiatives. Such large distributed systems also raise number of challenges in terms of desi...