TRPV3 mediates itch and inflammation in keratinocytes plays an important role atopic dermatitis, however, whether how is involved the pathogenesis of acne remains unclear. Thus, we explored effects on sebaceous glands (SGs) inflammation, its relation to cutibacterium acnes (C.acnes), underlying mechanisms vitro vivo. Our study found that overexpression activated Toll-like receptor 2 (TLR2)- Nuc...

1 The Ca‐permeable cation TRPV3 channel: an emerging pivotal target for itch and skin diseases Gongxin Wang and KeWei Wang Department of Pharmacology, Qingdao University School of Pharmacy and Institute of Innovative Drugs, Qingdao University, 38 Dengzhou Road, Qingdao 266021, Shandong Province, China This article has not been copyedited and formatted. The final version may differ from ...

AIM To investigate the expression and distribution of the members of the transient receptor potential (TRP) channel members of TRP melastatin (TRPM) and TRP vanilloid (TRPV) subfamilies in rat prostatic tissue. METHODS Prostate tissue was obtained from male Sprague-Dawley rats. Reverse transcription polymerase chain reaction (RT-PCR) and quantitative real-time polymerase chain reaction (PCR) ...

Ethnopharmacological Relevance In this study, we investigated the effects of Tribulus terrestris fruit (Leguminosae, Tribuli Fructus, TF) extract on oxazolone-induced atopic dermatitis in mice. Materials and Methods TF extract was prepared with 30% ethanol as solvent. The 1% TF extract with or without 0.1% HC was applied to the back skin daily for 24 days. Results 1% TF extract with 0.1% HC...

We have previously shown that gain-of-function variations in transient receptor potential vanilloid-3 (TRPV3) underlay Olmsted syndrome, a rare hyperkeratotic skin channelopathy. In this study, we attempt to establish genotype‒phenotype correlation which has been unclear owing the rarity and heterogeneity of condition. identified five unreported TRPV3 (R416Q, R416W, L655P, W692S, L694P) three r...

Pachyonychia congenita (PC) is a rare keratinizing disorder characterized by thickened nails, painful and inflammatory palmoplantar keratoderma (PPK) blistering for which no standard treatment currently available. PC caused dominant mutations in keratin (KRT) 6A, 6B, 6C, 16 17 genes are involved wound healing epidermal barrier formation. Previous reports pointed to mTOR activation oxidative str...