BACKGROUND Although efficacy of aprepitant for suppressing emesis associated with single-dose cisplatin has been demonstrated, there are limited data on the antiemetic effect of this oral neurokinin-1 receptor antagonist during daily administration of cisplatin. Accordingly, we investigated the efficacy and safety of aprepitant in patients with head and neck cancer (HNC) receiving combination t...

The aim of this study was to determine the efficacy of a triple anti-Helicobacter therapy using omeprazole, amoxicillin and clarithromycin (OAC) in dogs. A total of 15 healthy adult stray dogs with naturally acquired Helicobacter infection were evaluated using polymerase chain reaction and rapid urease test. Subsequently, they received a 21-day triple regimen. One day after the discontinuation ...

BACKGROUND We assessed whether quadruple or triple-class therapy for the initial treatment of HIV-1 infection provides a virological benefit over standard triple therapy in patients with very high plasma viraemia. The assessment was made based on a national observational HIV cohort in the Netherlands. METHODS Inclusion criteria were age ≥18 years, treatment-naive, plasma viral load (pVL) ≥500...

Approximately half of the world’s population is infected by Helicobacter pylori [1], which causes various gastrointestinal diseases including gastritis, peptic ulcer, gastric mucosaassociated lymphoid tissue lymphoma, and gastric cancer [2,3]. Korean guidelines, which were revised in 2013, by the Korean College of Helicobacter and Upper Gastrointestinal Research strongly recommend that H. pylor...

Helicobacter Pylori has been closely linked to chronic gastritis, peptic ulcers and increased risk of gastric carcinoma. Oral cavity, in particular dental plaque in periodontal pockets, may be a possible reservoir harboring H. Pylori, and may therefore be involved in the gastric reinfection by the bacterium, even after triple therapy regimen. This report is an update of scientific data showing ...

OBJECTIVE To evaluate the efficacy and safety of omeprazole-based dual and triple regimens for the treatment of children with Helicobacter pylori infection. METHODS Twenty-two patients (3 with gastric ulcer, 12 with duodenal ulcer, and 7 with nodular gastritis alone) were studied. Twelve ulcer patients also had nodular gastritis. The dual regimen included a 2-week course of omeprazole (0.6 mg...

BACKGROUND Helicobacter pylori (H. pylori) treatment remains a challenge for physicians. Although highly effective, the standard sequential therapy fails in a certain number of patients. Moreover, the cure rate following a levofloxacin-amoxicillin second-line triple therapy seems to be decreasing. We tested the efficacy of modified 10-day sequential therapy, and an intensified levofloxacin-amox...

BACKGROUND Most international guidelines recommend triple-therapy regimens consisting of a proton pump inhibitor, clarithromycin, and amoxicillin/metronidazole for at least 7 days for the eradication of Helicobacter pylori. However, the efficacy of 7-day clarithromycin-based standard triple therapy for H. pylori infection is currently unacceptable in Korea. In this study, we will compare the ef...

Helicobacter pylori (H. Pylori) infection is currently recognized as the major cause of chronic active gastritis, peptic ulcer disease and mucosa associated lymphoid tissue (MALT) lymphoma and carcinoma of the stomach. Eradication of the infection will prevent the recurrence of the majority of such diseases. Different combined treatments have been tried in Iran for eradication of H. Pylori, but...