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Background: Since Positive Parenting Program (Triple-P) is one of the ways to improve parent-child interaction, it seems that conducting a meta-analysis will help determine the actual effect size of Triple-P. The aim of this study was to meta-analyze the effect of level 4 Triple-P on interaction of parent-child with special needs in Iran. Methods: The current study is a meta-analysis. Before t...

STIM1 (stromal interaction molecule 1) mediates SOCE (store-operated Ca²⁺ entry) in skeletal muscle. However, the direct role(s) of STIM1 in skeletal muscle, such as Ca²⁺ release from the SR (sarcoplasmic reticulum) for muscle contraction, have not been identified. The times required for the maximal expression of endogenous STIM1 or Orai1, or for the appearance of puncta during the differentiat...

Coronavirus envelope (E) proteins play an important, not fully understood role(s) in the virus life cycle. All E proteins have conserved cysteine residues located on the carboxy side of the long hydrophobic domain, suggesting functional significance. In this study, we confirmed that mouse hepatitis coronavirus A59 E protein is palmitoylated. To understand the role of the conserved residues and ...

Protein phosphorylation keeps circadian clocks wound, triggering rhythmic transcriptional events throughout the day. This week, Lin et al. identify phosphorylation sites on the Drosophila circadian protein PERIOD (PER). Mutations in casein kinase 2 (CK2) result in abnormal circadian phenotypes and altered PER nuclear localization, and CK2 specifically phosphorylates PER in vitro. The authors fo...

The Coronary Artery Surgery Study (CASS) was designed to compare medical and surgical treatment of selected patients with chronic, stable coronary artery disease. This report concerns a subset of patients with reduced ventricular function. Of 780 patients randomly assigned to medical or surgical treatment, 160 had ejection fractions above 0.34 but below 0.50 at base line and have been followed ...

Cyclosporine (CsA) is the current primary immunosuppressant for the prevention of renal allograft rejection. Its chronic use is associated with various adverse effects like hypertension, hyperlipidemia, and nephrotoxicity, which in turn may contribute to chronic allograft nephropathy and cardiovascular mortality. This study compares a CsA-free maintenance regimen of mycophenolate mofetil (MMF) ...

BACKGROUND Many of the currently used Helicobacter pylori eradication regimens fail to cure the infection due to either antimicrobial resistance or poor patient compliance. Those patients will remain at risk of developing potentially severe complications of peptic ulcer disease. AIM We studied the impact of the antimicrobial resistance on the efficacy of a short course pantoprazole based trip...

This article presents the accounts of China’s Total Material Requirement (TMR) during 1995–2008, which were compiled under the guidelines of Eurostat (2009) and with the Hidden Flow (HF) coefficients developed by the Wuppertal Institute. Subsequently, comparisons with previous studies are conducted. Using decomposition, we finally examine the influential factors that have changed the TMR of Chi...