A new route is presented to prepare analogs of nucleosides homologated at the 3 and 5 -positions. This route, applicable to both the and -enantiomeric forms, is suitable for the preparation of monomeric bishomonucleosides needed for the synthesis of oligonucleotide analogs. It begins with the known monobenzyl ether 3 of pent-2-yne-1,5-diol, which is reduced to alkenol 4. Sharpless asymmetric ep...

The Queensland fruit fly, Bactrocera tryoni (Froggatt) (Q-fly), is a major horticultural pest in Eastern Australia. Effective monitoring, male annihilation technique (MAT) and mass trapping (MT) are all important for control and require strong lures to attract flies to traps or toxicants. Lure strength is thought to be related in part to volatility, but little vapour pressure data are available...

A general procedure for the nucleophilic addition of organozinc halides with nitrones in the presence of trimethylsilyl chloride has been developed. Trimethylsilyl chloride was found to be both an indispensable reaction promoter and a ready hydroxylamine protective agent in these reactions. The produced O-(trimethylsilyl)hydroxylamines can be easily reduced into corresponding amines just by a z...

The selectivities of nucleophilic substitution reactions of tetrahydropyran acetals promoted by trimethylsilyl trifluoromethanesulfonate depend upon the reaction solvent. Polar solvents favor the formation of S(N)1 products, while nonpolar solvents favor S(N)2 products. Trichloroethylene was identified as the solvent most likely to give S(N)2 products in both C- and O-glycosylation reactions.

The [3+2]-cycloaddition of (trimethylsilyl)diazomethane (7) with 9H-fluorene-9-thione (1) at –60°C yields the spirocyclic 2,5-dihydro-5-trimethylsilyl-1,3,4-thiadiazole 10, which eliminates nitrogen at room temperature to give the 1,4-dithiane derivative 13 by dimerization of the intermediate fluorenethione (trimethylsilyl)methanide (11). This thiocarbonyl ylide can be trapped by 1 to give the ...

In the presence of magnesium and hexamethylphosphorictriamide, HMPT, trimethylchlorosilane, TMS-C1, reacts with cyanoepoxides to give related compounds. Ring cleavage at ? - position of cyanoepoxide, 1, followed by the addition of two trimethylsilyl groups leads to 2 then substitution of OSiMei by trimethylsilyl or H takes place to give ?, ? - bis (trimethylsilyl) nitrile or ? - trimethyls...

tic cis-benzenediol was present on both plates, with R, values of 0.21 and 0.24 respectively. Another portion of the thoroughly dried ether extract was treated with Bis (trimethylsily1)trifluoracetamide and trimethylchlorosilane for 30min at 90° C and the trimethylsilyl derivative injected into a Pye 104 chromatograph fitted with a glass column packed with 4% OV 255 on Chromosorb WHP and a flam...

Diazo(trimethylsilyl)methylmagnesium bromide readily reacted with various ketones and aldehydes to give the corresponding 2-diazo-(2-trimethylsilyl)ethanols. These were efficiently converted to indazoles bearing hydroxymethyl units at the 3-position by intermolecular [3 + 2] cycloaddition with benzynes.

By the reaction of a number of oligosilyl potassium compounds with (trimethylsilyl)chloromethane, derivatives containing the (trimethylsilyl)methyl substituent were prepared. Using X-ray single-crystal structure analysis and UV spectroscopy the conformational properties of some of the compounds were studied. It was found that the (trimethylsilyl)methylated examples exhibit UV absorption propert...

The alkoxycarbonylation of trimethylsilylacetylene has been studied in order to develop an atom economic sustainable synthesis 2‐(trimethylsilyl)acrylates, a family valuable intermediates. Pd(OAc) 2 combination with CH 3 SO H and diphenyl‐(pyridin‐2‐yl)phosphine or diphenyl‐(6‐methyl‐pyridin‐2‐yl)phosphine is active catalyst for the reaction affording mixtures sought 2‐(trimethylsilyl)acrylate ...