BACKGROUND The soil-transmitted helminth (STH), Trichuris trichiura colonises the human large intestine where it may modify inflammatory responses, an effect possibly mediated through alterations in the intestinal microbiota. We hypothesised that patent T. trichiura infections would be associated with altered faecal microbiota and that anthelmintic treatment would induce a microbiota resembling...

A double-blind placebo trial was conducted to determine the effect of moderate to high loads of Trichuris trichiura (whipworm) infection on the cognitive functions of 159 school children (age 9-12 years) in Jamaica. Infected children were randomly assigned to Treatment or Placebo groups. A third group of randomly selected uninfected children were assigned to a Control for comparative purposes. ...

Stool specimens were examined for the parasite Trichuris trichiura from 1,860 patients in 17 hospitals for the mentally subnormal in the U.K. It was found in 10 of these hospitals, and an overall incidence of 13.2% was recorded. Most cases occurred in the South, where the overall incidence was 36.3%.Difetarsone was used in the treatment of infestations in two hospitals, and proved to be very we...

Recent studies have cast doubt on the effectiveness of whipping horses during races and this has led to questions concerning its continuing justification. Furthermore, it has been argued that whipping tired horses in racing is the most televised form of violence to animals. The present study used de-identified data from a recent independent Australian poll (n = 1,533) to characterise the 26% of...

BACKGROUND The currently used anthelmintic drugs, in single oral application, have low efficacy against Trichuris trichiura infection, and hence novel anthelmintic drugs are needed. Nitazoxanide has been suggested as potential drug candidate. METHODOLOGY The efficacy and safety of a single oral dose of nitazoxanide (1,000 mg), or albendazole (400 mg), and a nitazoxanide-albendazole combinatio...