Phosphines and phosphites are critical tools for non-metal desulfurative methodologies due to the strength of P=S bond. An overarching premise in these methods has been that stoichiometric (or excess)...

A novel class of chiral 5,5'-di(2,4,6-trialkyl)aryl salen-metal complexes have been developed and shown to catalyze highly enantioselective Nazarov cyclization reactions, giving rise to cyclopentenoids in 90:10-98:2 er. Significantly, the catalysts also promote, for the first time, highly enantioselective Nazarov reactions of "unactivated" dienones, producing hydrindenone products having in pla...

A new approach for the synthesis of two enantiomers ?-phosphorus-containing ?-amino acids was developed via Michael addition secondary phosphine oxides and dialkyl phosphites to chiral Ni(ii)-complexes a dehydroalanine-Schiff base.

Phosphorothioate has proven to be a useful skeleton in organic synthesis as a valuable building block, in pharmaceuticals and pesticides due to its biological and physical properties. In particular, S-aryl phosphorothioate represents an important structural element in antiproliferative agents (A), pesticides (B), antibacterials (C), curing accelerators (D), antistatic agents (E), and anticholin...

A little cooperation goes a long way: The cooperative Brønsted/Lewis acid-base supramolecular catalysts formed in situ from simple chiral magnesium(II) binaphtholate aqua complexes promoted the highly enantioselective 1,4-hydrophosphinylation of α,β-unsaturated esters with diaryl phosphine oxides and 1,2-hydrophosphonylation of α,β-unsaturated ketones with dialkyl phosphites (see scheme).

N-Heterocyclic carbenes catalyzed hydrophosphonylation reaction of α-ketoesters and α-trifluoromethyl ketones was developed. Under the catalysis of 10 mol% IPr, α-ketoesters or α-trifluoromethyl ketones reacted with dialkyl phosphites to provide quaternary α-hydroxyphosphonates in good to excellent yield.

In the title triangulo-triruthenium compound, [Ru(3)(C(6)H(12)Cl(3)O(3)P)(CO)(11)], one equatorial carbonyl ligand is substituted by a monodentate phosphite ligand, leaving one equatorial and two axial carbonyl ligands on one Ru atom. The remaining two Ru atoms each carry two equatorial and two axial terminal carbonyl ligands. In the crystal structure, the mol-ecules are linked into a one-dimen...

A novel, convenient and efficient multi-component reaction for synthesis of phosphonate derivatives from activated acetylenic compounds with 2-hydroxyacetophenone in the presence of phosphites in water lead to the formation of phosphonates in good yields.