In silico differential genomics helps to identify genes that encode for unique metabolism with relation to human. The genomic database provides a vast amount of useful information for the drug target identification. The subtractive dataset obtained comparatively between the human and the pathogen genome, differentially provides information about the genes that are likely to be essential to the ...

8. Phelps RG, Knispel J, Schuman Tu E, Cernainu G, Saruk M. Immunoperoxidase technique for detecting spirochetes in tissue sections: camparison with other methods. Int J Dermatol. 2000;39:609--13. 9. Buffet M, Grange P, Gerhardt P, Carlotti A, Calvez V, Bianchi A, et al. Diagnosing Treponema pallidum in secondary syphilis by PCR and immunohistochemistry. J Invest Dermatol. 2007;127:2345--50. 10...

The titres of treponema-specific and antilipoidal 19S(IgG) antibodies were determined in rabbits infected intratesticularly with Treponema pallidum. One group of rabbits was treated with penicillin the other served as control. Using different serological tests it was shown that 19S(IgM) antibodies were still detectable eight months after infection at about the same titres in both groups. In con...

We investigated the evolution of 6 genes from the Treponema pallidum repeat (tpr) gene family, which encode potential virulence factors and are assumed to have evolved through gene duplication and gene conversion events. The 6 loci (tprC, D, G, J, I, and K) were sequenced and analyzed in several members of the genus Treponema, including the 3 subspecies of human T. pallidum (T. pallidum subsp. ...

Variation in the expression of the different Tpr proteins in the syphilis spirochete, Treponema pallidum subsp. pallidum, may have important implications in its ability to evade host immune detection and cause persistent infection. In the present study we examined the pattern of antibody responsiveness to different Tpr members during infection with three isolates of T. pallidum. There was varia...

In addition to its effect on Trichomonas vaginalis, metronidazole has also been found to be active against the organisms causing Vincent's gingivitis. This has raised the question of its possible action on Treponema pallidum, although Scott-Gray and Murrell (1961) found that a short course of 1-8 g. given over 48 hours did not affect a case of primary syphilis, and Yobs, Clark, and Schroeter (1...

Sexually transmitted infections (STIs) are caused by a wide variety of bacteria, viruses, and parasites that are transmitted from one person to another primarily by vaginal, anal, or oral sexual contact. Syphilis is a serious disease caused by a sexually transmitted infection. Syphilis is caused by the bacterium Treponema pallidum subspecies pallidum. Treponema pallidum (T. pallidum) is a motil...