OBJECTIVE Following traumatic brain injury, disruption of blood-brain-barrier and consequent brain edema are critical events which might lead to increasing intracranial pressure (ICP), and nerve damage. The current study assessed the effects of aqueous date fruit extract (ADFE) on the aforementioned parameters. MATERIALS AND METHODS In this experimental study, diffused traumatic brain injury ...

traumatic brain injury (tbi) is one of the major causes of severe disability and death in the entire world that accidents are mentioned as main factors of it. tbi lead to primary and secondary injuries.  primary injuries are created immediately after accidents or bleeding but the secondary injuries are created by complicated process of cellular and molecular responses following primary injury a...

Objective(s): Neuroprotective effects of female gonadal steroids are mediated through several pathways involving multiple peptides and receptors after traumatic brain injury (TBI). Two of these peptides are including the regulatory peptides neuromedin U (NMU) and neuromedin S (NMS), and their common receptor neuromedin U2 receptor (NMUR2). This study investigates the effects of physiological do...

Traumatic brain injury (TBI) is the leading cause of mortality and disability among male adolescents and young adults; and mild traumatic brain injury is the most common type of traumatic brain injury. The disruption of blood-brain barrier (BBB) plays an important role in brain trauma. Previously, we have found that slit2, a member of slit protein family, increases permeability of BBB. In the p...

• Cerebral concussion and mild traumatic brain injury (TBI) have been used interchangeably, although the two terms have different definitions. • Traumatic axonal injury (TAI) is a more severe subtype of TBI than concussion or mild TBI. • In this review article, we reviewed the history of TAI in patients with concussion and mild TBI. Brain Neurorehabil. 2016 Sep;9(2):e1 https://doi.org/10.12786/...

Traumatic brain injury (TBI) is a major cause of morbidity and mortality in children. After TBI, the vulnerable to additional injuries (secondary injuries) because disrupts normal autoregulatory defense mechanisms. These secondary play crucial role patient prognosis. Posttraumatic seizures are an important leading further damage injured brain. Continuous monitoring by electroencephalography (EE...

  Objective(s): Brain edema is one of the most serious causes of death within the first few days after trauma brain injury (TBI). In this study we have investigated the role of Shilajit on brain edema, blood-brain barrier (BBB) permeability, intracranial pressure (ICP) and neurologic outcomes following brain trauma.   Materials and Methods: Diffuse traumatic brain trauma was indu...

Traumatic brain injury (TBI) leading to 5 million deaths annually is 1 of the 5 major causes of morbidity and mortality worldwide. In Iran, accidents are the main cause of death in youth as well as a dominant factor in reducing quality of life. In developing countries TBI incidence as one of the worst consequences of these accidents is growing due to wide use of motor-vehicles. Therapeutic stra...

Abstract Introduction Traumatic brain injury (TBI) is a global public health burden. Although neurogenesis occurs post-injury, achieving long term survival of newly generated neurons remains elusive. High Mobility Group Box protein 1 (HMGB1) pivotal cytokine in hosting the neuro-inflammatory response to injury, but also mediates during physiological development. In this review, we examine curre...