Leukocyte infiltration into inflammatory sites is regulated by the expression of adhesion and activation proteins, yet the role of these proteins in shear-dependent transmigration is poorly understood. We examined eosinophil recruitment on cytokine-stimulated human umbilical vein endothelial cells (HUVECs) under laminar flow conditions. Eosinophils rapidly transmigrated on interleukin (IL)-4-, ...

Neutrophil transmigration requires the localization of neutrophils to endothelial cell junctions, in which receptor-ligand interactions and the action of serine proteases promote leukocyte diapedesis. NB1 (CD177) is a neutrophil-expressed surface molecule that has been reported to bind proteinase 3 (PR3), a serine protease released from activated neutrophils. PR3 has demonstrated proteolytic ac...

In each of Plato's major cosmological works, the Timaeus , the Statesman myth and the Philebus , he asserts that the body of the whole universe is alive and possesses a single WorldSoul which extends throughout it. I wish to offer a new interpretation of the role of the World-Soul which gives the World-Soul a special function in the economy of the Platonic cosmology and which explains why Plato...

the dual nature of human existence, and having both physical and spiritual affairs have been accepted by religious scholars and divine philosophers . most philosophers, especially muslim  philosophers, despite the disagreement on  the way of soul creation have agreed about the soul creation itself and lack of its precedence over body .at least we can prove this idea with two arguments from ebne...

The leukocyte integrin lymphocyte function-associated antigen 1 (LFA-1) and its endothelial ligand intercellular adhesion molecule (ICAM)-1 play an important role in transmigration as demonstrated by in vivo and in vitro models of inflammation. Despite the prominent role, little is known concerning the distribution and dynamic behavior of these adhesion molecules during leukocyte transmigration...

All-trans retinoic acid (ATRA) can induce acute respiratory distress syndrome in patients with acute promyelocytic leukaemia (APL). The current study investigated the role of monocyte chemotactic protein (MCP)-1 in the chemotactic transmigration of ATRA-treated NB4 (ATRA-NB4) APL cells toward A549 alveolar epithelial cells. NB4 and A549 cells were separately cultured with ATRA and/or dexamethas...

though plato and sohravardi appearantly have the same view on the essence of human soul and the way in which it belongs to body, there are fundam ental differences in their point of view and their style as well. this paper deals with soul which is believed by both philosophers to be the origin of the human’s soul at first and, then, expresses their idea and reasonings about the occurance and an...

The purpose of this paper is to present the first case of unusual reverse oblique (110 degrees to midsagittal plane) migration of mandibular right canine crossing the jaw midline and piercing the lower border of the mandible at the level of the opposite canine and also to report two more cases of transmigrated mandibular canine and one case of transmigrating mandibular canine. Mandibular canine...