نتایج جستجو برای: translational research
تعداد نتایج: 1445090 فیلتر نتایج به سال:
Understanding the parallel evolutions of Big Data and Translational Medicine, and the types of disruptive technology that bring them together, requires a look back at their evolution and a discussion of the hindrances in applying big data techniques to translational medicine. We will then take a look into the future, at the concept of the "Complete Health Record" and how that may change the ver...
In the United Kingdom, many foundations and institutions and the government have made substantial investments in translational research. We examine the structures that surround this support and consider some of the results of this prodigious push toward enhancing translational research pursuits and thus improved clinical medicine.
What is translational medicine? This question has been vigorously debated by various constituencies for many years. One recent, encompassing definition of translational medicine was developed for the Strategic Plan in service of the American Society for Clinical Pharmacology and Therapeutics (ASCPT).1,2 Not coincidentally, the ASCPT Strategic Plan was aptly entitled “Transforming Translation.”
Clinical research is burdened by inefficiencies and complexities, with a poor record of trial completion, none of which is desirable. The Clinical and Translational Science Award (CTSA) Consortium, including more than 60 clinical research institutions, supports a unified national effort to become, in effect, a virtual national laboratory designed to identify, implement, evaluate, and extend pro...
Widespread use of microarray technology that led to highly complex datasets often is addressing similar or related biological questions. In translational medicine research is often based on measurements that have been obtained at different points in time. However, the researcher looks at them as a progression over time. If a biological stimulus shows an effect on a particular gene that is rever...
These are exciting times for translational medicine as the convergence between fundamental and clinical research comes of age. The new EMBO Press publishing platform reinforces the standing of EMBO Molecular Medicine as the journal that matches high quality, novel research with rigorous editorial and ethical standards. It will also cement the journal's global reach and relevance whether in high...
This review focuses on recent developments in the molecular mechanisms by which Ca activates cardiac sarcomeres and how these mechanisms play out in the cardiac cycle. I emphasize the role of mechanisms intrinsic to the sarcomeres as significant determinants of systolic elastance and ventricular stiffening during ejection. Data are presented supporting the idea that processes intrinsic to the t...
Review paper and Proceedings of the Inaugural Meeting of the Head and Neck Optical Diagnostics Society (HNODS) on March 14th 2009 at University College London. The aim of our research must be to provide breakthrough translational research which can be applied clinically in the immediate rather than the near future. We are fortunate that this is indeed a possibility and may fundamentally change ...
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