In adult mammalian brains, neural stem cells (NSCs) exist in the subventricular zone (SVZ), where persistent neurogenesis continues throughout life. Those NSCs produce neuroblasts that migrate into the olfactory bulb via formation of transit-amplifying cells, which are committed precursor cells of the neuronal lineage. In this SVZ niche, cell-cell communications conducted by diffusible factors ...

The subventricular zone (SVZ) is the largest germinal layer in the adult mammalian brain and comprises stem cells, transit-amplifying progenitors, and committed neuroblasts. Although the SVZ contains the highest concentration of dividing cells in the adult brain, the intracellular mechanisms controlling their proliferation have not been elucidated. We show here that loss of the cyclin-dependent...

Local bus network is the most popular transit mode and the only available transit mode in the majority of cities of the world. Increasing the utility of this mode which increases its share from urban trips is an important goal for city planners. Timetable setting as the second component of bus network design problem (network route design timetable setting vehicle assignment crew assignment) hav...

Introduction: Defining watershed (WS) areas – the border zone regions supplied by the most distal branches of the cerebral arteries – is critical as these regions are most susceptible to haemodynamic ischaemia, and may even play a role in thrombo-embolic stroke due to reduced wash-out of capacity. Territorial arterial spin labelling (TASL) has been shown to provide a method of selectively label...

Root growth is modulated by environmental factors and depends on cell production in the root meristem (RM). New cells in the meristem are generated by stem cells and transit-amplifying cells, which together determine RM cell number. Transcription factors and chromatin-remodeling factors have been implicated in regulating the switch from stem cells to transit-amplifying cells. Here, we show that...

The characterization of the atmospheres of habitable-zone Earth-mass exoplanets that transit across main-sequence stars, let alone the detection of biomarkers in their atmospheres, will be challenging even with future facilities. It has been noted that white dwarfs (WDs) have long-lived habitable zones and that a large fraction of WDs may host planets. We point out that during a transit of an E...