BACKGROUND   It is well known that blood transfusion is life-saving, but also that it carries a serious risk of transmitting viral infections. Introduction of new methods of testing for transmissible diseases, blood banking and dispatch regulations has considerably increased the cost of blood products. However, the clinical benefits and cost-effectiveness of allogeneic red-blood-cell (ARBC) tra...

Improvements in donor screening and testing and viral inactivation of plasma derivatives together have resulted in substantial declines in transfusion-transmitted infections over the last two decades. Most recently, nucleic acid testing techniques have been developed to screen blood and plasma donations for evidence of very recent viral infections that could be missed by conventional serologic ...

1. Transfusion medicine. Technical manual, 2nd ed. WHO; 2003. p. 151. 2. Garg S, Mathur DR, Garg DK. Comparison of seropositivity of HIV, HBV, HCV and syphilis in replacement and voluntary blood donors in western India. Indian J Pathol Microbiol 2001;44:409-12. 3. Nanu A, Sharma SP, Chatterjee K, Jyoti P. Markers for transfusion transmissible in north Indian voluntary and replacement blood dono...

Despite all blood donations being tested routinely for HBsAg as a clinical marker of transmissible HBV, cases post-transfusion hepatitis B virus infection are still reported because molecular studies using Polymerase Chain Reaction (PCR) not available Transfusion Transmissible Infection (TTIs) testing. In this study, we sought to use the PCR technique re-screen donated that had already been pro...

Abstract Background Assuring safety and survival of blood in vitro depends on anti-coagulation substances, blood bag characteristics, storage conditions, and transport of blood. Besides, careful selection and screening of donors as well as blood tests can minimize the transmission risk of blood-transmissible pathogens and optimize blood health. The aim of this study was to assay the level of ...