Many spices, including plants of the ginger family, possess anticarcinogenic activity. However, the molecular mechanisms by which they exert their antitumorigenic effects are unknown. Activator protein 1 (AP-1) has a critical role in tumor promotion, and blocking of tumor promoter-induced activation of AP-1 inhibits neoplastic transformation. Epidermal growth factor induces cell transformation ...

The aim of this work is to study the iteration of a transformation defined for families of sets. Let P be a family of disjoint and nonempty sets S1, ..., Sk, then pick from each set an element and remove it, suppress the sets that become empty and add one new set composed of all the picked elements. It leads to a new family of sets, and our concern is the way the cardinalities of the sets evolv...

To deal with software requirements volatility, we present a model transformation of a software family requirements model into detailed requirements models of its members. This transformation is based on feature algebra and relation algebra. We give the mathematical foundation for this transformation system. The initial models are the result of engineering requirements processes. In other terms,...

Many parents assert that, despite the considerable and sustained stresses involved in parenting a child with a disability, their experiences have been personally transformative. Increasingly, researchers are advocating for a theoretical understanding of family life management following the diagnosis of disability in a child, with an emphasis on family strengths and resilience, attestations of p...

Transformation from a parametric family can improve the performance of kernel density estimation. In this paper, we give two data-driven estimators for the optimal transformation parameter. We demonstrate that multiple families of transformations can be employed at the same time, and there can be beneets to iterating this process. The transformation scheme can be expected to rst pick the right ...

Signal transducer and activator of transcription (STAT) proteins perform key roles in mediating signaling by cytokines and growth factors, including platelet-derived growth factor (PDGF). In addition, Src family kinases activate STAT signaling and are required for PDGF-induced mitogenesis in normal cells. One STAT family member, Stat3, has been shown to have an essential role in cell transforma...

The mouse Wnt family includes at least 10 genes that encode structurally related secreted glycoproteins. Wnt-1 and Wnt-3 were originally identified as oncogenes activated by the insertion of mouse mammary tumor virus in virus-induced mammary adenocarcinomas, although they are not expressed in the normal mammary gland. However, five other Wnt genes are differentially expressed during development...