Plasma glutathione S-transferase (GST) measurements have been used to study early changes in hepatocellular integrity after paracetamol overdose and treatment with N-acetylcysteine (NAC). Patients admitted within seven hours and successfully treated had raised or equivocal GST on admission and each showed a transient peak in GST approximately 12 hours after the overdose. Similar, though smaller...

Glutathione transferase P (GST-P; glutathione transferase, EC 2.5.1.18) is known to be specifically expressed at high levels in precancerous lesions and in hepatocellular carcinomas from a very early phase of chemically induced hepatocarcinogenesis in the rat. The almost invariable occurrence of this phenotype in these lesions strongly suggests a mechanism by which GST-P gene is activated toget...

OBJECTIVE Oxidative stress plays an important role in the pathogenesis of type 1 diabetes mellitus (T1DM). To evaluate the association of glutathione S-transferase mu 1 (GST M1) and glutathione S-transferase theta 1 (GST T1) polymorphisms with development of T1DM and disease-related risk factors. METHODS Measurement of fasting glucose, serum creatinine, lipid profile, and glycosylated hemoglo...

Elevated levels of neutrophil elastase in CPOD (Chronic Obstructive Pulmonary Disease) airways are regarded as the main trigger lung destruction and inflammation. SLPI (Secretory leukocyte protease inhibitor), an inhibitor protease, represents attractive candidate for treatment chronic diseases due to proteases excess. The antiprotease active site has been located on C-terminal domain. This stu...

Insulin-dependent diabetes mellitus (IDDM) is a metabolic condition that induces blood glucose levels to rise due insulin deficiency and the formation of reactive oxygen species (ROS). The purpose this study assess how efficient antioxidant extracts Tribulus terrestris (TT) metformin (MET) are in reducing oxidative stress histopathology produced by streptozotocin rat hepatocytes. 36 male rats w...

Glutathione transferase (GST) activity and GST isoenzyme composi tion have been determined for 24 human neoplasms and 6 human tumor cell lines. Substantial activity (40-1010 milliunits/mg protein) was iden tified in all tumor specimens examined and three of the tumor cell lines. Three tumor cell lines, the human small cell carcinoma line SW2-10S, the Burkitt's lymphoma derived cell line Raji, a...

Glutathione S-transferase (GST), an enzyme system which conjugates glutathione to a vanety of xenobiotics with electrophllic centres was found dunng the GEEP Workshop m the digesbve glands of the s n d httorina httorea and the mussel Myllus edulis, and in the hepatopancreas of the crab Carcinus maenas GST activity was significantly higher in crabs from 2 polluted sites m Langesundfjord Norway r...

Glutathione transferase (GST) activity and GST isoenzyme composi tion have been determined for 24 human neoplasms and 6 human tumor cell lines. Substantial activity (40-1010 milliunits/mg protein) was iden tified in all tumor specimens examined and three of the tumor cell lines. Three tumor cell lines, the human small cell carcinoma line SW2-10S, the Burkitt's lymphoma derived cell line Raji, a...

Glutathione-S-transferases (GST) are key phase II detoxifying enzymes that play critical roles in protection against products of oxidative stress and against electrophiles. Glutathione S-transferase mu (GST-M1) and theta (GST-T1) are isoforms of glutathione transferase enzymes that participate in the metabolism of a wide range of chemicals. Deletion variants that are associated with a lack of e...

Multidrug resistance correlates with unfavourable treatment outcomes in numerous cancers including renal cell carcinoma. The expression and clinical relevance of Glutathione-S-transferase-pi (GST-pi), a multidrug resistance factor, in kidney tumors remain controversial. We analyzed the expression of GST-pi in 60 formalin-fixed, paraffin-embedded renal cell carcinoma samples by immunohistochemis...