The aim of the study was to formulate and evaluate topically applied ketoprofen gels and patches and to see the effect of naturally occurring almond oil as penetration enhancer on the penetration of ketoprofen through artificial membrane/rabbit skin. Prior to ketoprofen gel and patch formulation, the particle size and particle size determination of ketoprofen was analyzed by Particle size analy...

A dminMed is developing an innovative line of novel microneedle-based transdermal drug delivery devices. The current pipeline comprises an advanced microneedle arraybased pen-injector device (the AdminPen) that painlessly and conveniently injects therapeutic levels of standard liquid pharmaceutical drugs or cosmetic actives through the skin. This breakthrough technology revolutionizes the way i...

Rotigotine, a nonergot dopamine agonist, has been developed as a novel transdermal formulation. The rotigotine transdermal patch has received EMA and FDA marketing authorization for the treatment of adult patients with early or advanced Parkinson’s disease or with moderate-to-severe restless legs syndrome (RLS). This review comprises an overview of the pharmacokinetics, the pharmacodynamics and...

Transdermal drug delivery system offers best way of through skin than compared to oral route administration by overcoming side-effects.Drug is done adhesion transdermal patches surface.Novel application techniques have been employed for better therapeutic response various in treatment several disease using dermal administration.This non-invasive method reducing frequency achieve complete action...

BACKGROUND The purpose of this study was to develop a transdermal ligustrazine patch containing a stable formulation and with good entrapment efficiency, release rate, and transdermal absorption. METHODS Ligustrazine ethosomes were prepared by ethanol injection-sonication, with entrapment efficiency as an indicator. Using acrylic resin as the primary constituent, the ligustrazine ethosome pat...

Transdermal drug delivery is the application of drug on the skin surface so that it can permeate through the skin and reaches the systemic circulation at sufficient concentration to ensure therapeutic efficacy. Transdermal drug delivery system (TDDS) has several advantages over conventional system; TDDS offers sustained drug release, avoidance of first pass effect, patient compliance, ease of a...

Purpose LifeWave Corp has developed non-transdermal energy enhancer patches that stimulate acupuncture points in order to heighten energy by enhancing the autonomic regulation of blood vessels and hence improving circulation. A laser Doppler perfusion imager was used to determine microvascular perfusion of the index, middle and ring finger tips pre and post application of the patches on wrist a...

Pain is a prevalent condition in patients with cancer, particularly in advanced stages of cancer. Although strong opioids are the mainstay of cancer pain management protocols, patients are often undertreated. Transdermal buprenorphine is currently available for the treatment of moderate to severe cancer pain and severe pain which does not respond to nonopioid analgesics; patch doses of 35, 52.5...