Transdermal drug delivery system appears to be most promising delivery system due to their merits over conventional delivery systems. Recently, various strategies have been used to augment the transdermal delivery of bioactives. Mainly, they include iontophoresis, electrophoresis, sonophoresis, chemical permeation enhancers, microneedles, and vesicular system (liposomes, niosomes, elastic lipos...

The purpose of the present study was to develop a novel transdermal drug-delivery system comprising a polyamidoamine dendrimer coupled with sonophoresis to enhance the permeation of diclofenac (DF) through the skin. The novel transdermal drug-delivery system was developed by using a statistical Plackett-Burman design. Hairless male Wistar rat skin was used for the DF-permeation study. Coupling ...

In the present work, monolithic matrix transdermal systems containing Drug x were prepared using various ratios of the polymer blends of hydroxy propyl methyl cellulose (HPMC) and Eudragit S 100 (ES) with triethyl citrate as a plasticizer. A 32 full factorial design was employed. The concentration of HPMC and ES were used as independent variables, while percentage drug release was selected as d...

Proliposomes are an innovative kind of carrier-mediated drug delivery that offers numerous advantages over traditional liposomes. The conventional liposomes susceptible to oxidation or hydrolysis, as well sedimentation, aggregation, fusion with other substances. While, proliposomes far more stable than liposomes, making them better suited for the pharmaceuticals. They a dry, free-flowing, granu...

Polymers are the backbone of a transdermal drug delivery system as they control the release of the drug from the device. Biodegradable polymers attracts the attention of its use as they can be degraded to non-toxic monomers and most important, a constant rate of drug release can be achieved from a biodegradable polymer based controlled release device. Natural polymers can be used as the means o...

Drugs are administered by using different drug delivery systems. A number of drug delivery systems have evolved over the years. In the last 20 years TDDS (Transdermal drug delivery system) has been growing at a rapid pace. Now the micro needles are being developed as a novel drug delivery system. The micro needle skin patch system is also a drug delivery system, which will be used transdermally...

Over many millennia, natural products were the only means for food, to treat diseases and injuries. Recently in the field of pharmaceutical sciences great efforts are being directed towards herbal drugs by incorporating them in already existed drug delivery system to solve the problem related to poor solubility, poor bioavailability, dosing problem, stability, toxicity etc. Curcumin is a yellow...

Transdermal Drug Delivery System (TDDS) is described as a self-contained or discrete dosage form that applied to the intact skin. This rout of drug administration drugs through skin for therapeutic use an alternative approach oral, intravascular, subcutaneous, and transmucosal routes. The delivery systemic circulation provides convenient route variety clinical indications. allows continuous adm...