In the development of neuroinflammatory diseases, alterations of the blood brain barrier (BBB) represent key events. The integrity of the BBB is partially maintained by endothelia cells (ECs), since they actively limit the transmigration of immune cells. However, the factors that cause endothelial cells to develop an immune cell-permissive phenotype are poorly understood. In general, it has bee...

Background: DiGeorge syndrome critical region gene 5 (DGCR5) has been shown to be associated with cancer development. However, the biological role and molecular mechanism of DGCR5 in pancreatic (PC) remains largely unknown. Methods: qRT-PCR fluorescence situ hybridization was performed investigate correlation between expression prognosis clinicopathologic characteristics PC patients. The effect...

The mammalian target of rapamycine (mTOR) pathway is a key regulator of cellular growth, development, and ageing, and unraveling its control is essential for understanding life and death of biological organisms. A motif-discovery workbench including nine tools was used to identify transcription factors involved in five basic (Insulin, MAPK, VEGF, Hypoxia, and mTOR core) activities of the mTOR p...

rho-kinase is an effector molecule of rhoa, a monomeric gtp-binding protein, and causes ca2+ sensitization through inactivation of myosin phosphatase. the major physiological functions of rho/rho-kinase cascade include contraction, proliferation and migration in cells.there are some excellent reviews about rho/rho-kinase signal pathway, most of which focus on the specific proteins of the pathwa...

The presence of morphine alkaloids, anti-microbial and anti-cancer metabolite, sanguinarine, in different species of Papaver genus has made it one of the most valuable plants in the pharmaceutical industry.With regard to the influence of drought and salinity on the increase of secondary metabolites, the present study attempted to investigate the effect of the mentioned stresses on the key genes...

Lipopolysaccharide can induce myocardial cell injury, which has been widely used in the preparation of septic cardiomyopathy models. We herein aimed to evaluate protective effects sodium hydrosulfide against oxidative stress and endoplasmic reticulum on model explore whether protein kinase RNA-like kinase-eukaryotic initiation factor 2 alpha signaling pathways was involved. The sepsis induced e...

The Solanaceae plants produce a variety of interesting biologically active products including the steroid alkaloids solanidine, nicotine and tropane alkaloids. Putrescine N-methyltransferase (PMT) is an enzyme that catalyses s-adenosylmethionine-dependent methylation of putrescine in one of the primary steps of nicotine and tropane alkaloids biosynthesis pathway. Two tobacco members of the AP2/...