A group of eukaryotic cell surface proteins are anchored to the outer leaflet of the plasma membrane by glycosylphosphatidylinositol (GPi). in human cells, about 150 GPi-anchored proteins of various functions, such as hydrolytic enzymes, receptors, protease inhibitors, adhesion molecules, and complement regulatory proteins, have been known, and more will be added to the list. GPi is a glycolipi...

Celiac Disease (CD) or gluten sensitive enteropathy is an autoimmune disorder characterised by variable presentations which respond to exclusion of wheat and other gluten containing products [1]. While exclusion of gluten is the corner stone in the management of this entity, newer therapeutic approaches are now being investigated. These include use of elemental diets, oral prolyl-endopeptidases...

Oxyimides have gained wide interest in different applications because of radical generating properties, such as flame retardants various polymers. As polyamide-6 (PA6) is highly flammable and shows burning dripping during incineration the mentioned issues to be overcome by use a retardant. All previously developed oxyimides already show these but this based on ester structure with consequence t...

ABSTRACT The classical neurotransmitter serotonin or 5-hydroxytryptamine (5-HT), synthesized from tryptophan, can be produced both centrally and peripherally. Through binding to functionally distinct receptors, is profoundly implicated in a number of fundamental physiological processes pathogenic conditions. Recently, has been found covalently incorporated into proteins, newly identified post-t...

Thioamides represent highly valuable isosteric in the strictest sense “single-atom substitution” analogues of amides that have found broad applications chemistry and biology. A long-standing challenge is direct transamidation thioamides, a process which would convert one thioamide bond (R?C(S)?NR1R2) into another (R?C(S)?NR3N4). Herein, we report first general method for thioamides by chemosele...