BACKGROUND Schizophrenia (SZ) is associated with psychotic experiences and cognitive deficits. Therefore, cognitive function is one of the most critical determinants of quality of life in this pathology. Resveratrol has been related to neuroprotective action, but there are no studies evaluating resveratrol in SZ. The objective of this study was to determine the efficacy of resveratrol supplemen...

Content of trans-resveratrol, trans-ε-viniferin and trans-δ-viniferin in young spring grapevine canes – the influence samples drying | Naděžda Vrchotová, Jan Tříska, Radomíra Střalková, Štěpán Horník, Sýkora, Josef Balík, Ivo Soural, Lukáš Toupal, Radek Sotolář Agricultural Journals

Although the natural polyphenol resveratrol posses a direct vasorelaxant effect, its effects on cytoplasmic Ca(2+) concentration ([Ca(2+)](i)) in vascular cells remain still unclear. Here, we have investigated the effects of the isomers trans- and cis-resveratrol on agonist- and high-K(+)-induced [Ca(2+)](i) increases and on voltage-activated transmembrane Ca(2+) fluxes using imaging and patch-...

Resveratrol (3,5,4′-trihydroxystilbene) (Fig. 1) was first isolated in 1940 as an ingredient of the roots of white hellebore (Veratrum grandiflorum O. Loes) and has since been found in about 70 plant species, including grapes, mulberries and peanuts.1 It can also be found in food products and beverages such as peanut butter, red wine and grape juice.2,3 It provides cardioprotection in red wine ...

Resveratrol (Res) is a type of natural plant stilbenes and phytoalexins that only exists in a few plant species. Studies have shown that the Res could be biosynthesized and accumulated within plants, once the complete metabolic pathway and related enzymes, such as the key enzyme resveratrol synthase (RS), existed. In this study, a RS gene named PNRS1 was cloned from the peanut, and the activity...

Background: Glucose uptake by muscles and fat cells is carried out by the GLUT4 system. Isoforms of the SNAP23, syntaxin-4 and VAMP-2 play an important role in regulating GLUT-4 trafficking and fusion in adipocytes. The changes of SNARE proteins levels and thus impaired GLUT-4 displacement can be one of the etiological causes of type 2 diabetes.Due to changes in the expression of these proteins...

BACKGROUND Strong interindividual differences in the microbial conversion of some dietary polyphenols have been reported. In-depth studies of trans-resveratrol metabolism by human gut microbiota, however, are lacking, and only one bacterial metabolite, namely dihydroresveratrol, has been described. OBJECTIVE The aim of this study was to elucidate interindividual differences in trans-resveratr...

Sulfur dioxide is a controversial preservative used in winemaking. Given its potential toxicity, it of great interest to find alternatives aimed at replacing or reducing sulfur dioxide. The objective was assess the antioxidant effects grapevine-shoot extract with 99% stilbenes (ST-99), major compounds (trans-resveratrol and trans-?-viniferin) their mixture (1:3.9) by measuring reactive oxygen s...