Xylazine hydrochloride, α2 adrenoceptor agonist, is an analgesic, sedative, tranquilizer, and muscle relaxant agent in veterinary medicine which is mostly used as in pre-anesthesia in veterinary medicine. One of the main adverse effects of xylazine which limits application of this medication in small animal veterinary practice (mostly in cats) is nausea and vomiting which can end up with aspira...

gamma-amino butyric acid (gaba) possesses several physiological functions such as neurotransmission, induction of hypotension, diuretic and tranquilizer effects. production of gaba-enriched products by lactic acid bacteria has been a focus of different researches in recent years because of their safety and health-promoting specifities. in this study, glutamate decarboxylase (gad) gene of a loca...

Why is this an issue?
 
 The opioid crisis ongoing public health concern in Canada. In 2022, a total of 7,328 apparent toxicity deaths were reported, which average 20 per day.
 Xylazine, referred to as tranq, animal tranquilizer that has appeared adulterant the unregulated drug supply (particularly opioids) and contributing increasing numbers poisoning (overdose) events deaths.&#...

The aim of the present study was to explore effect three selective sedative/tranquilizer drugs i.e. Xylazine(XZ), Acepromazine(AC), and Diazepam(DZ) on normal physiological parameters such aspulse, respiration, body temperature serum glucose.All Xylazine, Acepromazine, Diazepam were used at dose rate 8mg/kg, 5 mg/kgand diazepam1mg/kg respectivelythrough intramuscular route(I.M.)in six healthy r...