Semliki Forest virus (SFV) has been extensively studied as a model for analyzing entry of enveloped viruses into target cells. Here we describe the trace of the polypeptide chain of the SFV fusion glycoprotein, E1, derived from an electron density map at 3.5 A resolution and describe its interactions at the surface of the virus. E1 is unexpectedly similar to the flavivirus envelope protein, wit...

Our archival researches at the Royal Society reveal that a small envelope attached to a 1675 letter from an Antwerp apothecary, A. Boutens, contained a sample of the 'Ludus' prepared as a remedy for the 'stone disease' then sweeping through Europe, which was first announced in J. B. van Helmont's De lithiasi (1644). After examining the fascination with the medical use of the Ludus (which requir...

Connections between glaciation, chemical weathering, and the global carbon cycle could steer the evolution of global climate over geologic time, but even the directionality of feedbacks in this system remain to be resolved. Here, we assemble a compilation of hydrochemical data from glacierized catchments, use this data to evaluate the dominant chemical reactions associated with glacial weatheri...

We report the detection, with the Caltech Submillimeter Observatory, of the 894-GHz HDO(11,1−00,0) transition, observed in absorption against the background continuum emission of the SgrB2 cores M and N. Radiative transfer modeling of this feature, together with the published data set of mm and submm HDO and H 2 O transitions, suggests that ground-state absorption features from deuterated and n...

background: asthma is a multifactorial disease and its severity varies with the inflammatory grade. there are conflicting reports about the roles of trace elements in asthma. this study examined the effects of zinc (zn), copper (cu), and selenium (se) concentrations in sera of patients with allergic asthma attending ghaem hospital, mashhad, iran. methods: forty-nine patients, aged 10 to 50 year...

background: the method of proton induced x-ray emission (pixe) has been widely used as a sensitive technique to trace elemental analysis in both biological and medical fields. the sensitivity of this powerful method is in the order of ppm .the aim of this work is to analyze structural composition of 4 heavy trace elements with z greater than 24 (mn, fe, cu, zn) in two kinds of gallstones and to...

Hepatitis B virus consists of an outer envelope and an inner capsid, or core, that wraps around the small genome plus the viral replication enzyme. The icosahedrally symmetric nucleocapsid is assembled from multiple dimeric subunits of a single 183-residue capsid protein, which must therefore contain interfaces for monomer dimerization and for dimer multimerization. The atomic structure of the ...

underground caverns in rock salt deposits are the most secure disposal method and a type of gas-storing facility. gas storage plays a vital role in ensuring that a strategic relationship is secured between an established energy infrastructure provider and a midstream energy company. the fischells brook area is a pillow-shaped body of salts located in the st. george's bay area of southwest newfo...

background: proton induced x-ray emission (pixe) has been applied as reliable and improved techniques in this study to compare concentration of various trace elements in normal and abnormal varicose veins. materials and methods: five samples from normal veins and 13 samples from varicose veins bombarded by 2.0 mev energy proton beams produced by a van de graff accelerator in vacuum. two specime...

this study assesses the effect of major trace metals levels in wastewater discharges and sedimentfrom twenty four permanent and five semi-permanent wastewater drain outlets into the kuwait coast. theeffect of trace metals levels released from untreated wastewater discharges to euchelus asper, gastropod was also determined. results showed high trace metal levels in e. asper tissues, followed by ...