PURPOSE The study aimed to investigate a relationship between the mineral content of human trabecular bone and parameters determined from compression fatigue tests at stepwise-increasing amplitude. METHODS Mineral content of trabecular bone was estimated comparing density and bone mineral density values. The relationship between the ash density, bone mineral density and factors obtained from ...

Basic fibroblast growth factor (FGF-2), an important modulator of cartilage and bone growth and differentiation, is expressed and regulated in osteoblastic cells. To investigate the role of FGF-2 in bone, we examined mice with a disruption of the Fgf2 gene. Measurement of trabecular bone architecture of the femoral metaphysis of Fgf2(+/+) and Fgf2(-/-) adult mice by micro-CT revealed that the p...

Background: The trabecular bone changes in the tibia of C3H/HeN mice were measured 12 weeks after whole body irradiation with various doses of fast neutrons (0-2.4 Gy) or 137Cs-generated gamma-rays (0-6 Gy). Materials and Methods: Serum calcium, phosphorus, estradiol concentration and alkaline phosphatase activity were measured. Tibiae were anal...

In mature trabecular bone, both density and trabecular orientation are adapted to external mechanical loads. Few quantitative data are available on the development of architecture and mechanical adaptation in juvenile trabecular bone. We studied the hypothesis that a time lag occurs between the adaptation of trabecular density and the adaptation of trabecular architecture during development. To...

Prologned spaceflight results in bone loss in astronauts, but there is considerable individual variation. The goal of this rat study was to determine whether gender influences bone loss during simulated weightlessness. Six-month-old Fisher 344 rats were hindlimb unweighted for 2 wk, after which the proximal tibiae were evaluated by histomorphometry. There were gender differences in tibia length...

OF THESIS REFERENCE POINT INDENTATION OF HUMAN TRABECULAR BONE TREATED WITH BISPHOSPHONATES FOR VARYING DURATIONS Reference point indentation (RPI), a novel form of micro-indentation, quantifies RPI material parameters which correlate with modulus, yield stress, strength, or toughness. Information linking bisphosphonate treatment length with the material properties of osteoporotic trabecular bo...

Bone is the living composite biomaterial having unique structural property. Presently, there is a considerable gap in our understanding of bone structure and composition in the native state, particularly with respect to the trabecular bone, which is metabolically more active than cortical bones, and is readily lost in post-menopausal osteoporosis. We used solid-state nuclear magnetic resonance ...

Introduction The estimation of failure parameters of bone are clinically relevant as in our aged society bone injuries are having greater economic impact. At the macro scale, bone is mainly composed of cortical and trabecular bone. Trabecular bone has major importance in the failure process in bone. The highly hierarchical structure of bone makes it necessary to study its different scales to in...