Multiple myeloma (MM) is a B cell malignancy characterized by clonal proliferation of plasma cells in the bone marrow. With the advent of novel targeted agents, the median survival rate has increased to 5 -7 years. However, majority of patients with myeloma suffer relapse or develop chemoresistance to existing therapeutic agents. Thus, there is a need to develop novel alternative therapies for ...

PURPOSE The purpose of the study was to assess the responses of pial artery pulsation (cc-TQ) and subarachnoid width (sas-TQ) to acetazolamide challenge in patients with chronic carotid artery stenosis and relate these responses to changes in peak systolic velocity (PSV), cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT) and time to peak response (TTP). METHODS F...

Glioblastoma is the most aggressive and common type of malignant brain tumor in humans, with a median survival of 15 months. There is a great need for more therapies for the treatment of glioblastoma. Naturally occurring phytochemicals have received much scientific attention because many exhibit potent tumor killing action. Thymoquinone (TQ) is the bioactive compound of the Nigella sativa seed ...

1.1. Fix a surjective morphism of fine monoids π : P → Q, and let j : AQ ↪→ AP be the corresponding closed immersion, where AP := Spec(k[P ]) and AQ := Spec(k[Q]). Assume further that the associated groups P gp and Q are torsion free, and that Q is sharp. Let TP (resp. TQ) denote the torus associated to the group P gp (resp. Q) so that TP acts on AP and TQ acts on AQ. The map π induces an inclu...

Methods Observational study of a cohort of patients admitted to ICU during 2012, requiring elective tracheostomy (TQ), according with the actual technique protocol. Demographic variables were analysed, Apache II scale, previous pathologies, MV days, stay and mortality; globally and by groups depending on early or late TQ. In our model, patients were divided into early and late TQ, using the fou...

BACKGROUND Restitution through intracardiac pacing has been used to assess arrhythmia vulnerability. We examined whether analyses of sequential beat-to-beat QT and TQ interval measures can be used to quantify ECG restitution changes under normal sinus rhythm. METHODS The QT, R-R and TQ intervals were examined 22.5 hour Holter monitoring before and after oral sotalol in normal male and female ...

Cyclophosphamide (CYP) induced hemorrhagic cystitis is a dose-limiting side effect involving increased oxidative stress, inflammatory cytokines and suppressed activity of nuclear factor related erythroid 2-related factor (Nrf2). Thymoquinone (TQ), an active constituent of Nigella sativa seeds, is reported to increase the expression of Nrf2, exert antioxidant action, and anti-inflammatory effect...

Colorectal cancer (CRC) is one of the most prevalent cancers and has a high mortality rate. Insensitivity and the limited therapeutic efficacy of its standard chemotherapeutic drug, 5-fluorouracil (5-FU), represents an important challenge in CRC treatment. The robust antitumor properties of thymoquinone (TQ), the main bioactive constituent of Nigella sativa, have recently been demonstrated on d...

We demonstrate the use of triple quantum (TQ) filtered sodium MRI in a group of patients undergoing clinical evaluation for primary brain tumors. The TQ images were acquired using a twisted-projection readout in tandem with a three-pulse triple quantum filter. Our results demonstrate that TQ sodium MRI provides a source of contrast that it is not biased by the large sodium content of the extrac...