Preliminary studies have shown that the bioassay based on inhibition of alpha-glucosidase biosynthesis (AGB) in Bacillus licheniformis is useful in the acute toxicity screening of environmental samples. Alpha-glucosidase is an extracellular enzyme induced by the presence of maltose in the environment of the cell. The enzyme degrades maltose into glucose residues acting at the 1, 4-alpha-glycosi...

To discover novel antimalarial and anticancer compounds, we carried out a genome analysis, bioassay, metabolite profiling, molecular docking of marine sediment actinobacteria strain GMY01. The whole-genome sequence analysis revealed that Streptomyces sp. GMY01 (7.9 Mbp) is most similar to sennicomposti RCPT1-4T with an average nucleotide identity (ANI) ANI based on BLAST+ (ANIb) values 98.09 97...

The unpredictable clinical toxicity observed in patients treated with mitomycin C and the observation that this agent must be reduced to an active form before alkylating target molecules have led to the development of a bioassay which is capable of detecting biologically active forms of mitomycin C in the plasma of drug-treated patients. The bioassay makes use of a repairdeficient mutant of Chi...

Background: Phenol and nitrophenol are common compounds found in different types of industrial wastewater known as serious threats to human health and natural environment. In this study, Daphnia magna was used to evaluate the effectiveness of "baffle fixes film up flow sludge blanket filtration" (BFUSBF) system in elimination of phenolic compounds from water. Methods: D. magna cult...