The main challenge of immunosuppressive therapy after solid organ transplantation is to create a new immunological balance that prevents rejection and does not promote opportunistic infection. Torque teno virus (TTV), ubiquitous non-pathogenic single-stranded DNA virus, has been proposed as marker functional immunity in immunocompromised patients. Here we investigate whether TTV loads predict t...

An infectious etiology has been proposed for many human cancers, but rarely have specific agents been identified. One difficulty has been the need to propagate cancer cells in vitro to produce the infectious agent in detectable quantity. We hypothesized that genome amplification from small numbers of cells could be adapted to circumvent this difficulty. A patient with concomitant chronic lympho...

Abstract Background Immunosuppression including high-dose calcineurin inhibitors (CNI) is essential after lung transplantation. Dosing usually guided by therapeutic drug monitoring adjusted to target trough levels of CNIs keep the balance between over-dose causing severe toxicity and increased risk infections or under-dose with a graft injury. Adaptation CNI-based immunosuppression torque teno ...

24 The family Anelloviridae includes human and animal Torque teno viruses (TTV) with extensive 25 genetic diversity. The antigenic diversity among anelloviruses has never been assessed. Using 26 Torque teno sus virus (TTSuV) as a model, we describe here the first investigation on antigenic 27 relationships among different anelloviruses. Using the TTSuV1a or TTSuV1b ELISA based on 28 the respect...

BACKGROUND Lung transplant patients are a vulnerable group of immunosuppressed patients that are prone to frequent respiratory infections. We studied 60 episodes of respiratory symptoms in 71 lung transplant patients. Almost half of these episodes were of unknown infectious etiology despite extensive routine diagnostic testing. METHODS We re-analyzed respiratory samples of all episodes with u...

RATIONALE Idiopathic pulmonary fibrosis is a progressive, uniformly fatal interstitial lung disease. An acute exacerbation of idiopathic pulmonary fibrosis is an episode of acute respiratory worsening without an identifiable etiology. Occult viral infection has been proposed as a possible cause of acute exacerbation. OBJECTIVES To use unbiased genomics-based discovery methods to define the ro...

SUMMARY The risk of transfusion-transmitted infections has been greatly reduced by improvements in donor screening and testing. However, newly recognized blood-borne infectious agents can be threats to blood safety. In order to evaluate the prevalence some of these agents in blood donors, a systematic review was conducted. Data were obtained from published papers related to HGV, Torque Teno vir...

In order to verify the microbial quality of the influents and effluents of one STP from southern Brazil, an eight-month survey was conducted to examine the presence of total and fecal coliforms and of adenovirus (HAdV), enterovirus (EV), genogroup A rotaviruses (GARV) and Torque teno virus (TTV), in treated effluent samples from São João/Navegantes STP, Porto Alegre (Brazil). A total of 16 samp...

Adenovirus (AdV), enterovirus (EV), genogroup A rotaviruses (GARV) and Torque teno virus (TTV) are non-enveloped viral agents excreted in feces and so may contaminate water bodies. In the present study, the molecular detection of these viruses was performed in samples of surface water collected from the Arroio Dilúvio, a waterstream that crosses the city of Porto Alegre, RS, Brazil, receiving g...

BACKGROUND Cirrhosis is one of the most severe liver complications, with multiple etiologies. The torque teno virus (TTV), also known as transfusion transmitted virus, which has a high incidence in the world population, is one of the possible increasing risk factors in patients with idiopathic fulminant hepatitis and cryptogenic cirrhosis. OBJECTIVES The aim of this study was to evaluate soli...