purpose: to report a case of unilateral aspergillus fumigatus interface keratitis after laser in situ keratomileusis (lasik). case report: a 22-year-old woman developed corneal infiltrates located at the flap- stroma interface in her left eye 48 hours after myopic lasik. the infiltration progressed despite administration of topical fortified antibiotics therefore, the flap was lifted and irriga...

A 3-month-old male red fox that was in contact with a Persian cat referred to the small animal hospital, Faculty of Veterinary Medicine, University of Tehran with multi-focal circular non-pruritic skin lesions and hair loss mainly on the head and extremities. A complete series of dermatologic tests such as Wood’s light examination, direct microscopic examination, and fungal culture were perform...

Ketoconazole (Ketoconazole HRA™), an imidazole derivative, is a useful treatment option in the management of endogenous Cushing’s syndrome adults and adolescents > 12 years age, based on evidence from more than three decades use drug clinical practice. Originally developed as antifungal agent, ketoconazole potent steroidogenesis inhibitor. Approximately 60% (range, 45–88% across key studies) pa...

Ketoconazole is an imidazole oral antifungal agent with a broad spectrum of activity. Ketoconazole has been reported to cause liver damage, but the mechanism is unknown. However, ketoconazole and a related rug, miconazole, have been shown to have inhibitory effects on oxidative phosphorylation in fungi. Fluconazole, another orally administered antifungal azole, has also been reported to cause l...

Seborrheic dermatitis (SD) is normally treated with topical corticosteroids and antifungals. Oral therapies can be prescribed in severe or unresponsive cases. This review aims to assess the quantity and quality of published reports on oral therapies for SD. MEDLINE and Embase databases and the reference listings of publications were searched for any publication using oral treatment for SD. The ...

A 7-year-old boy was brought for evaluation of a rash on the chin that had appeared 2 weeks earlier. It was slightly itchy. The mother had applied a topical corticosteroid for a few days but then stopped because of worsening of the lesion. The erythematous, scaly lesion with a well-defined border on this boy's face is characteristic of tinea faciei. As the lesion spreads peripherally, the cente...

Vulvovaginal candidiasis (VVC), the second most common form of vaginitis, particularly affects women of childbearing age. Since the 1970s, several new agents have become available for the treatment of VVC. This review focuses on options for the treatment of this condition, critically evaluating the relevant published studies. For the treatment of acute episodes of VVC in nonpregnant women, seve...

The purpose of this review was to investigate the management of oral candidiasis in HIV/AIDS patients and to evaluate the different guidelines available for its management. A number of topical and systemic antifungal medications are used to treat oral candidiasis in HIV-positive patients. Milder episodes of oral candidiasis respond to topical therapy with nystatin, clotrimazole troches or oral ...

We previously demonstrated that ketoconazole is a potent inhibitor of triazolam biotransformation in vitro and in vivo. Despite significant elevations in triazolam plasma levels with coadministration of ketoconazole, the pharmacodynamic enhancement was lower than predicted based on plasma levels of triazolam. The present study examines the effects of ketoconazole on benzodiazepine receptor bind...

Prophylaxis with intermittent or continuous ketoconazole One RCT found that oral ketoconazole (given either intermittently or continuously at a lower dose) versus placebo significantly reduced symptomatic recurrences over 6 months (NNT 2–4). Ketoconazole is associated with an increased frequency of gastrointestinal adverse effects, and case reports have associated ketoconazole with a low risk o...