CORTISONE and hydrocortisone are now widely used in the treatment of ocular inflammations, particularly in allergic conditions such as phlyctenular keratoconjunctivitis, vernal conjunctivitis, scleritis, uveitis, and some kinds of keratitis. In the treatment of diseases in the anterior segment of the eye, an inexpensive topical application in the form of a suspension or ointment may be used wit...

Dermatitis caused by bombardier beetles is rarely reported. Here, we report a case of beetle-caused dermatitis that occurred in Pará State, the Brazilian Amazon. A female patient while putting on her shoes, felt a burning pain in the right hallux and noticed a beetle inside the shoe. During medical consultation, the physician observed that the injury site was brown and discolored. The patient c...

In a recent question about abnormal hair-growth, the writer mentioned a long history of hydrocortisone use as a means of treating eczema. I too have a long history of severely uncomfortable and troubling eczema. During the worst outbreaks, I have visited several different dermatologists, and all have prescribed topical hydrocortisones, such as Hytone or Topicort, as well as anti-itching pills, ...

Paederus dermatitis is an irritant contact dermatitis due to accidental contact by a beetle belonging to the genus paederus. In this study, clinical efficacies of S. ebulus fruit extract solution in patients affected by paederus dermatitis were evaluated. A randomized double-blind, prospective, placebo-controlled clinical trial was performed in 62 patients with clinical symptoms and sings of de...

OBJECTIVES: The penetration of hydrocortisone (HC) from six topical over-the-counter products along with one prescription cream through cultured normal human-derived epidermal keratinocytes (Epiderm™), mouse skin and synthetic nylon membrane was performed as well as the effect hydrating the skin by pre-washing was explored using the Upright Franz Cell. METHOD AND RESULTS: Permeation of HC throu...

Topical 5-aminosalicylic acid (5-ASA) and corticosteroids are used frequently in the treatment of active distal ulcerative colitis (UC). Our study aimed to determine the efficacy and safety of different topical drugs used to treat active distal UC. A random-effects model within a Bayesian framework was utilized to compare treatment effects and safety as odds ratios (ORs) with corresponding 95% ...

The discovery of the therapeutic properties of certain steroids has recently given rise to interesting chemical and pharmacological problems. The remarkable antiphlogistic activities of halogenated derivatives of hydrocortisone, and the disappearance of secondary effects obtained by the A1-diene derivatives of cortisone, have suggested the synthesis of a steroid which joins the two chemical cha...