The purpose of this study was to investigate microemulsions as delivery systems for diclofenac sodium (DS). Microemulsion systems were composed of: soybean oil, nonionic surfactants (Brij 58 and Span 80), and different alcohols: ethanol, and 1-buthanol as cosurfactant. The optimum surfactant: cosurfactant (S:CoS) weight ratios and microemulsion areas were detected by the aid of ternary phase di...

Patients with tendon and ligament injuries often see their family physician for care. Rest, ice, compression, elevation (RICE) therapy is fi rst-line treatment for these injuries. Oral NSAIDs, such as diclofenac, piroxicam, and ibuprofen reduce swelling and lead to a more rapid return to activity than RICE alone in patients with ankle sprains, and relieve pain associated with muscle strains, to...

pumose To compare the efficacy of topical indomethicin, dicMenac and ketorolac as pain relief following excimer laser P.R.K. &&Q&s Double masked, random&d trial involving 360 patients. Au patients rece.ived a standard regime of one of the trial dmgs and chloramphenicol ointment to be used four times daily for 3 days. Pain levels were assessed on B I ocm linear aMlogue scale prior to each instil...

Background and objectives: Dorema ammoniacum gum resin is used in Iranian traditional medicine for different indications including inflammatory diseases which are on the rise. Considering the important role of inflammation in different diseases, in the present study, we aimed to investigate the in vivo anti-inflammatory activity and skin toxicity of Dorema ammoniac...

I have read with interest the brief communication entitled “Treatment of alopecia areata by topical diclofenac sodium gel in comparison to benzoyl peroxide. A novel single blind therapeutic clinical trial” by Sharquie et al.1 The author suggested the use of diclofenac gel as an irritant in alopecia areata, which in other words, by causing inflammation of the affected area but diclofenac has an ...

Background: Darier’s disease (DD) is an autosomal dominant skin disorder which causative gene, ATP2A2, is located at chromosome 12q23–24. The lesions of DD are skin-coloured to brown, hyperkeratotic, greasy papules that coalesce into warty plaques commonly involving the seborrhoeic areas of the trunk and face, especially the scalp margins, temples, ears, and scalp. The most common complaint ass...

PURPOSE We report a case of acute corneal melt with perforation in a patient with keratoconus after collagen crosslinking treatment and the use of topical diclofenac and proparacaine eyedrops. METHODS The authors present a case report with clinicopathologic correlation. RESULTS A patient diagnosed with keratoconus underwent corneal collagen crosslinking followed by postoperative use of oflo...