Vitamin D plays a role in the process of melanogenesis, namely increasing L-Dopa cells, inducing differentiation immature melanocytes, and melanocyte activity. The use vitamin dermatology is treatment vitiligo, psoriasis vulgaris, atopic dermatitis, verruca alopecia. Vitiligo an autoimmune disease skin form depigmentation due to destruction melanocytes by T cells. clinical manifestations vitili...

the present work compared the clinical efficacy of ropically applied vitamin d3 (cholecalciferol), i a, 25 dihydroxy vitamin d3 (cakitriol) with calcipotriol (dovonex} in the treatment of plaque psoriasis. a randomized, double - blind, left - right, vehicle controlled study to assess the therapeutic efficacy and safety of mice daily application of 1 pg/g and 5 fj.g1g chalecakiferol. 1 pglg calc...

Non-keratinocyte cutaneous malignancies including breast cancer metastasis and melanoma in situ are often poor surgical candidates due to their anatomical location, size the morbidities associated with surgery. Imiquimod, a toll-like receptor 7 agonist, is used for treatment of these malignancies, which activates innate immunity skin. However, imiquimod’s modest effect on activation adaptive li...

INTRODUCTION Sorafenib is a multitargeted potent antiangiogenic tyrosine kinase inhibitor. Sorafenib has antiproliferative and antineoplastic effects in addition to antiangiogenic effects. According to research, the use of sorafenib is effective in the treatment of advanced hepatocellular carcinoma. However, sorafenib has several side effects including hand-foot skin reaction, alopecia, and Ste...

Psoriasis is a chronic inflammatory condition. The age of onset, chronicity, physical, and psychosocial consequences of the disease cause psoriasis to have a significant impact on patient quality of life. Scalp psoriasis is no different, and effective treatment results in an improvement in quality of life. Successful management of scalp psoriasis includes topical therapies that are acceptable t...

Topical therapy continues to be one of the pillars of psoriasis management. Topical corticosteroids and vitamin D analogs are the drugs of choice during the induction phase, and vitamin D analogs continue to be drugs of choice for maintenance therapy. Tazarotene and dithranol are suitable options in patients with certain, specific characteristics. The calcineurin inhibitors can be considered to...

A 56-year-old man with chronic hepatitis C was treated with pegylated interferon alfa-2a in combination with ribavirin. However, psoriatic lesions appeared and worsened dramatically during therapy. Because of the extensive skin eruptions, he stopped therapy for chronic hepatitis C and subsequently started narrow-band ultraviolet B phototherapy and topical calcipotriol/betamethasone dipropionate...

We report a case of 61-yr-old man with stable psoriasis who progressively developed generalized pustular eruption, erythroderma, fever, and hepatic dysfunction following oral terbinafine. Skin biopsy was compatible with pustular psoriasis. After discontinuation of terbinafine and initiating topical corticosteroid and calcipotriol combination with narrow band ultraviolet B therapy, patient's con...