background the goal of the present study was the preparation and evaluation of griseofulvin topical gel as a drug dosage form with appropriate efficacy and stability. material and methods to select the best formulation, formulations with different concentration of carbomer and hpmc were evaluated for their appearance. then evaluated for physicochemical characteristics such as rheologic behavior...

Microsponge containing ketotifen drug with three different proportions of ethyl cellulose and drug were obtained successfully using quasi-emulsion solvent diffusion method. These formulations were studied for particle size and physical characterization. These microsponges enriched gel formulation were prepared by using 2 and 3 % w/w of SCMC and studied for viscosity, pH, gel strength, spreadabi...

The present study concerned with the development and characterization of metronidazole microcapsules prepared by thermal change method using different ratios (1:1, 1:2 and 1:4) of ethyl cellulose in order to select the best microcapsule formulation with a good encapsulation efficiency and drug release profile. The obtained microcapsules were discrete, spherical with free flowing properties and ...

BACKGROUND Rosacea is a chronic skin disease that requires long-term therapy. Oral antibiotics and topical metronidazole successfully treat rosacea. Because long-term use of systemic antibiotics carries risks for systemic complications and adverse reactions, topical treatments are preferred. OBJECTIVE To determine if the use of topical metronidazole gel (Metrogel) could prevent relapse of mod...

In the present study, chitosan was included in pectin ionotropic gel to improve its mechanical and bioadhesive properties. Pectin–chitosan gels P–Ch0, P–Ch1, P–Ch2, P–Ch3 of weight fractions 0.00, 0.25, 0.50, 0.75 were prepared characterized by dynamic rheological tests, penetration serosal adhesion ex vivo assays. The storage modulus (G′) loss (G″) values, hardness, elasticity P–Ch1 significan...

The present study aimed to investigate the delivery potential of Etodolac (ETD) containing topical niosomal gel. Niosomal formulations were prepared by thin film hydration method at various ratios of cholesterol and Span 60 and were evaluated with respect to particle size, shape, entrapment efficiency, and in vitro characteristics. Dicetyl phosphate (DCP) was also added in the niosomal formulat...

Down’s syndrome or trisomy 21 is man’s most frequent genetic disorder. It affects one out of 600-700 live births. It is characterized by the presence of an additional chromosome at the 21 pair which elicits generalized decrease of growth as well as intellectual disability. In scientifi c literature there are many reports of cranio-facial and oral manifestations of this disorder. Chief oral cond...

background: melaleuca alternifolia (tea tree) essential oil has been traditionally used in the ayurvedic system of medicine for healing burns, infections and seborrheic dermatitis. but yet, no controlled human study has determined its efficacy. objective: the goal of the current study was to compare the efficacy of 5% tea tree essential oil (tto) gel with placebo in the treatment of mild to mod...

introduction recently topical 3% diclofenac is commonly used to treat actinic keratosis (ak). it is proposed that it may also have a potential effect on hair growth. case presentation three male patients were visited in the dermatology department and received treatment with topical 3% diclofenac gel because of scalp ak. all patients also had concomitant androgenetic alopecia (aga). during the f...