Background Pomegranate can inhibit cytochrome P450 (CYP) 2C9 activity, which is largely responsible for the metabolism of sulfonylureas. The present study was undertaken to evaluate the pharmacokinetic and pharmacodynamic interaction of pomegranate and tolbutamide (TOL) against diabetic-induced complications. Methods Diabetes was induced via administration of alloxan (150 mg/kg, intraperitone...

Two hundred twenty women with prior cesarean section were delivered at our institution between January 1987 and February 1990. Vaginal delivery was achieved in 111 (66%) of 169 patients given a trial of labor (TOL). Success of TOL correlated positively with the number of prior vaginal deliveries (P less than 0.05) and inversely with the number of prior cesarean sections (P less than 0.005). Mat...

Reduction of [U(Ts(Tol))(Cl)(μ-Cl)U(Ts(Tol))(THF)2] [2, Ts(Tol) = HC(SiMe2NAr')3; Ar' = 4-MeC6H4)] with KC8 in toluene afforded the new arene-bridged diuranium complex [{U(Ts(Tol))}2(μ-η(6):η(6)-C6H5Me)] (3); combined structural, spectroscopic, magnetic, and computational analyses unambiguously confirm that the uranium centres in 3 are in the +5 oxidation state and the toluene is a 10π-tetraanion.

Donor hemopoietic cell engraftment is considered to be an indicator of allograft tolerance. We depleted chimerism with cells specifically presensitized to the bone marrow donor to investigate its role in mixed chimera-induced tolerance. Three experimental models were used: model A, B10.A cells presensitized to B6 (a anti-b cells) were injected into (B6 x D2)F(1) --> B10.A mixed chimeras grafted...

Cl = section lift coefficient c = local chord length D = fading-memory constant G = nondimensional circulation l = section lift force/length m = number of points used in sine series expansion of circulation function N = consecutive iterations convergence parameter r = perpendicular distance from vortex tol = iteration relative tolerance of conversion U1 = freestream velocity magnitude w = downw...

Wheat is a crop of global significance, grown in diversified environments. Heat stress affects number morpho-physiological traits crops including wheat. A set 40 wheat accessions along with four checks were screened for heat tolerance based on various indices. The present study was undertaken during rabi 2018-19 randomized block design having three replications at CCS Haryana Agricultural Unive...

Background. Ceftolozane/tazobactam (TOL/TAZ) is a novel antibacterial with activity against P. aeruginosa (PSA) and other common Gram-negative pathogens (GN). TOL/TAZ is currently under clinical development for the treatment of nosocomial pneumonia, complicated intra-abdominal infections and complicated UTIs. The in vitro activity of TOL/TAZ was tested against GN in patients hospitalized with p...

The Tower of London (TOL) task is widely used as a neuropsychological test of planning. Relatively little is known of the cognitive components of the task, and in particular the role of memory in performance. The current studies on normal adults looked at the role of verbal and spatial working memory in the TOL. The effects of verbal and visuospatial dual-task manipulations on TOL performance w...

in order to evaluate drought tolerance of some aegilops triuncialis ecotypes a factorial experiment based on a completely randomized design was conducted under non-stress and drought stress (irrigation until 50% of heading) condition in the greenhouse of mohaghegh ardabili university in 2012. drought tolerance and susceptibility indices for grain yield were calculated and principal component an...