نتایج جستجو برای: tme
تعداد نتایج: 1374 فیلتر نتایج به سال:
Objective. To investigate the effi cacy of preoperative short term radiotherapy in patients with mobile rectal cancer undergoing TME surgery. Summary Background Data. Local recurrence is a major problem in rectal cancer treatment. Preoperative short term radiotherapy has shown to improve local control and survival in combination with conventional surgery. The TME trial investigated the value of...
BACKGROUND We investigated very long-term bowel function after total mesorectal excision (TME) with or without preoperative short-course radiotherapy (PRT) for rectal cancer, the risk factors for bowel dysfunction, and the association of bowel dysfunction with health-related quality of life (HRQL). PATIENTS AND METHODS In the TME trial (1996-1999), 1530 Dutch patients with rectal cancer were ...
Epidemiologic studies have highlighted associations between the regular use of nonsteroidal anti-inflammatory drugs (NSAID) and reduced glioma risks in humans. Most NSAIDs function as COX-2 inhibitors that prevent production of prostaglandin E₂ (PGE₂). Because PGE₂ induces expansion of myeloid-derived suppressor cells (MDSC), we hypothesized that COX-2 blockade would suppress gliomagenesis by i...
The novel Bruton's tyrosine kinase inhibitor ibrutinib has demonstrated high response rates in B-cell lymphomas; however, a growing number of ibrutinib-treated patients relapse with resistance and fulminant progression. Using chemical proteomics and an organotypic cell-based drug screening assay, we determine the functional role of the tumour microenvironment (TME) in ibrutinib activity and acq...
In recent years, the relevance of the tumor microenvironment (TME) in the progression of cancer has gained considerable attention. It has been shown that the TME is capable of inactivating various components of the immune system responsible for tumor clearance, thus favoring cancer cell growth and tumor metastasis. In particular, effects of the TME on antigen-presenting cells, such as dendritic...
The purpose of this study was to investigate the changes of craniofacial morphology and tongue position in children with Class III malocclusion after tongue myofunctional exercises (TME). TME were applied to 25 patients with class III malocclusion for 1.01 ± 0.02 years. Lateral cephalograms were taken and cephalometric analysis was evaluated. Compared with the control group, facial angle, S-Ti ...
Four experiments were conducted to evaluate the effectiveness of a computer-controlled simulated digestion system (CCSDS) for predicting apparent metabolizable energy (AME) and true metabolizable energy (TME) using in vitro digestible energy (IVDE) content of feeds for roosters. In Exp. 1, the repeatability of the IVDE assay was tested in corn, wheat, rapeseed meal, and cottonseed meal with 3 a...
The consideration of the complex interplay between the tumour microenvironment (TME) and the immune response is the key for designing effective immunotherapies. Therapeutic strategies that harness co-stimulatory receptors have recently gained momentum in the clinic. One such strategy with promising clinical applications is the targeting of CD137, a member of the tumour necrosis factor receptor ...
Cancer progression is in part determined by interactions between cancer cells and stromal cells in the tumor microenvironment (TME). The identification of cytotoxic tumor-infiltrating lymphocytes has instigated research into immune stimulating cancer therapies. Although a promising direction, immunosuppressive mechanisms exerted at the TME hamper its success. Myeloid-derived suppressor cells (M...
In this work, we extend Achi Brandt’s notion of textbook multigrid efficiency (TME) to massively parallel algorithms. Using a finite element based geometric multigrid implementation, we recall the classical view on TME with experiments for scalar linear equations with constant and varying coefficients as well as linear systems with saddle-point structure. To extend the idea of TME to the parall...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید