نتایج جستجو برای: tlr2tlr4 heterodimer

تعداد نتایج: 5219  

2016
Yoshihito Moriwaki Tsutomu Yamane Hideaki Ohtomo Mitsunori Ikeguchi Jun-ichi Kurita Masahiko Sato Aritaka Nagadoi Hideaki Shimojo Yoshifumi Nishimura

During chromatin-regulated processes, the histone H2A-H2B heterodimer functions dynamically in and out of the nucleosome. Although detailed crystal structures of nucleosomes have been established, that of the isolated full-length H2A-H2B heterodimer has remained elusive. Here, we have determined the solution structure of human H2A-H2B by NMR coupled with CS-Rosetta. H2A and H2B each contain a h...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1997
S Minucci V Horn N Bhattacharyya V Russanova V V Ogryzko L Gabriele B H Howard K Ozato

Histone acetylation is thought to have a role in transcription. To gain insight into the role of histone acetylation in retinoid-dependent transcription, we studied the effects of trichostatin A (TSA), a specific inhibitor of histone deacetylase, on P19 embryonal carcinoma cells. We show that coaddition of TSA and retinoic acid (RA) markedly enhances neuronal differentiation in these cells, alt...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2003
David A Bushnell Roger D Kornberg

The x-ray structure of complete RNA polymerase II from Saccharomyces cerevisiae has been determined, including a heterodimer of subunits Rpb4 and Rpb7 not present in previous "core" polymerase II structures. The heterodimer maintains the polymerase in the conformation of a transcribing complex, may bind RNA as it emerges from the enzyme, and is in a position to interact with general transcripti...

Journal: :The Journal of Cell Biology 2006
Jin-A Lee Sue-Hyun Lee Changhoon Lee Deok-Jin Chang Yong Lee Hyoung Kim Ye-Hwang Cheang Hyoung-Gon Ko Yong-Seok Lee Heejung Jun Dusan Bartsch Eric R. Kandel Bong-Kiun Kaang

Long-term memory requires transcriptional regulation by a combination of positive and negative transcription factors. Aplysia activating factor (ApAF) is known to be a positive transcription factor that forms heterodimers with ApC/EBP and ApCREB2. How these heterodimers are regulated and how they participate in the consolidation of long-term facilitation (LTF) has not, however, been characteriz...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2010
Richard H G Baxter Stefanie Steinert Yogarany Chelliah Gloria Volohonsky Elena A Levashina Johann Deisenhofer

The leucine-rich repeat (LRR) proteins LRIM1 and APL1C control the function of the complement-like protein TEP1 in Anopheles mosquitoes. The molecular structure of LRIM1 and APL1C and the basis of their interaction with TEP1 represent a new type of innate immune complex. The LRIM1/APL1C complex specifically binds and solubilizes a cleaved form of TEP1 without an intact thioester bond. The LRIM1...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1998
R J Diebold N Rajaram D A Leonard T K Kerppola

Cooperative DNA binding by transcription factors that bind to separate recognition sites is likely to require bending of intervening sequences and the appropriate orientation of transcription factor binding. We investigated DNA bending in complexes formed by the basic region-leucine zipper domains of Fos and Jun with the DNA binding region of nuclear factor of activated T cells 1 (NFAT1) at com...

2003
DREW SCHWARTZ

EMPERATURE-sensitive mutations, i.e., mutations which render enzymes ‘inactive only at certain temperatures. have proven to be extremely useful in genetic analyses. Such mutations are usually detected by the inability of an organism to grow or carry out a particular function at high temperatures. In the course of ethyl methanesulfonate (EMS) niutation studies a temperature-sensitive allele of t...

Journal: :Molecular and cellular biology 1999
C Lee K Bae I Edery

The Drosophila CLOCK (dCLOCK) and CYCLE (CYC) (also referred to as dBMAL1) proteins are members of the basic helix-loop-helix PAS (PER-ARNT-SIM) superfamily of transcription factors and are required for high-level expression of the circadian clock genes period (per) and timeless (tim). Several lines of evidence indicate that PER, TIM, or a PER-TIM heterodimer somehow inhibit the transcriptional...

Journal: :The Journal of biological chemistry 2005
Keiko Y Petrosky Horng D Ou Frank Löhr Volker Dötsch Wendell A Lim

LIN-2/7 (L27) domains are protein interaction modules that preferentially hetero-oligomerize, a property critical for their function in directing specific assembly of supramolecular signaling complexes at synapses and other polarized cell-cell junctions. We have solved the solution structure of the heterodimer composed of the L27 domains from LIN-2 and LIN-7. Comparison of this structure with o...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2010
Takahiro Tanji Eun-Young Yun Y Tony Ip

The innate immune response in Drosophila involves the inducible expression of antimicrobial peptide genes mediated by the Toll and IMD signaling pathways. Dorsal and DIF act downstream of Toll, whereas Relish acts downstream of IMD to regulate target gene expression. Dorsal, DIF, and Relish are NF-kappaB-related transcription factors and function as obligate dimers, but it is not clear how the ...

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