نتایج جستجو برای: tlr

تعداد نتایج: 8542  

2015
Hyun Sook Hwang Su Jin Park Eun Jeong Cheon Mi Hyun Lee Hyun Ah Kim

INTRODUCTION Fibronectin fragments (FN-fs) are increased in the cartilage of patients with osteoarthritis (OA) and have a potent chondrolytic effect. However, little is known about the cellular receptors and signaling mechanisms that are mediated by FN-fs. We investigated whether the 29-kDa amino-terminal fibronectin fragment (29-kDa FN-f) regulates cartilage catabolism via the Toll-like recept...

Journal: :Trends in microbiology 2004
Mihai G Netea Jos W M Van der Meer Bart-Jan Kullberg

Toll-like receptors (TLRs) are probably the most important class of pattern-recognition receptors. Recognition of pathogen-associated molecular patterns (PAMPs) by TLRs, either alone or in heterodimerization with other TLR or non-TLR receptors, induces the production of signals that are responsible for the activation of genes important for an effective host defense, especially those of proinfla...

Journal: :American journal of physiology. Regulatory, integrative and comparative physiology 2004
Katherine A Barsness John Arcaroli Alden H Harken Edward Abraham Anirban Banerjee Leonid Reznikov Robert C McIntyre

Toll-like receptor 4 (TLR-4), initially identified as an LPS receptor, is critical to the signaling of a variety of danger signals, including heat shock protein 60, fibrinogen, and fibronectin. Recent data also suggest that TLR-4 plays a role in determining survival in both endotoxemia and hemorrhagic shock. We hypothesized that a functional TLR-4 would be required for hemorrhage and endotoxin-...

Journal: :Cellular immunology 2010
Risa K Benwell Jennifer E Hruska Kevin L Fritsche David R Lee

To better understand the relative efficiencies of using different TLR ligand-activated DCs to induce human CD4(+) T lymphocyte responses, human DCs were activated with two viral and two bacterial TLR ligands, and their production of IL12, TNFalpha, and IL10 was examined. While the two viral TLR ligands (ssRNA and dsRNA) induced DC production of detectable levels of IL12p70, DCs activated by the...

Journal: :The Journal of rheumatology 2011
Yasunobu Tamaki Yuya Takakubo Tomoyuki Hirayama Yrjö T Konttinen Stuart B Goodman Mitsunori Yamakawa Michiaki Takagi

OBJECTIVE Toll-like receptors (TLR) recognizing endogenous and exogenous danger signals could play a role in rheumatoid arthritis (RA). Our aim was to describe the presence, localization, and extent of expression of TLR and their adapters. METHODS TLR 1, 2, 3, 4, 5, 6, and 9 receptors, and myeloid differentiation primary response protein 88, Toll/interleukin receptor (TIR) domain-containing a...

2012
Ryan J. Stark Niloufar Aghakasiri Rolando E. Rumbaut

Endotoxin (lipopolysaccharide, LPS) produced by gram-negative bacteria initiates a host of pro-inflammatory effects through Toll-like receptor 4 (TLR-4). We reported previously that LPS enhances microvascular thrombosis in cremaster venules of wild-type mice, but had no effect in mice deficient in TLR-4. Since TLR-4 is expressed on various cell types, the cellular origin of TLR-4 responsible fo...

2014
Claudio Lera Orsatti Eliana Aguiar Petri Nahas Jorge Nahas-Neto Fabio Lera Orsatti Vanessa Innocenti Giorgi Steven S. Witkin Andrea Cignarella

OBJECTIVE To evaluate the gene expression of Toll-Like (TLR-2 and TLR-4) receptors and cytokine profile in postmenopausal women with or without metabolic syndrome (MetS). METHODS In this cross-sectional study, 311 Brazilian women (age≥45 years and amenorrhea≥12 months) were included. Women showing three or more of the following diagnostic criteria were diagnosed as positive for MetS: waist ci...

Journal: :Journal of immunology 2004
Andrew E Gelman Jidong Zhang Yongwon Choi Laurence A Turka

Toll-like receptor (TLR) engagement by pathogen-associated molecular patterns (PAMPs) is an important mechanism for optimal cellular immune responses. APC TLR engagement indirectly enhances activated CD4(+) T cell proliferation, differentiation, and survival by promoting the up-regulation of costimulatory molecules and the secretion of proinflammatory cytokines. However, TLRs are also expressed...

Journal: :Journal of immunology 2008
Vicky Lampropoulou Kai Hoehlig Toralf Roch Patricia Neves Elisabeth Calderón Gómez Claire H Sweenie Yi Hao Antonio A Freitas Ulrich Steinhoff Stephen M Anderton Simon Fillatreau

TLR sense microbial infections, and control activation of immune responses. Dendritic cells, macrophages, and B lymphocytes express TLR and the TLR-signaling adaptor protein MyD88. The impact of TLR-activated B cells on T cell-mediated inflammation is unknown. In this study, we have used mice carrying B cell-restricted deficiencies in MyD88 or in distinct TLR to examine the impact of TLR-activa...

Journal: :Journal of Vascular Surgery 2022

To report outcomes following endovascular revascularisation for severe aorto-iliac occlusive disease (AIOD) using covered (CS) or bare metal (BMS) stent(s). This was a retrospective cohort study including patients who underwent treatment with CS BMS AIOD between November 2012 and March 2020 in 12 European centres. Outcome measures included death, freedom from target lesion (TLR), major amputati...

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