A convenient and practical synthesis of imidazol-1-yl-acetic acid hydrochloride was achieved via N-alkylation of imidazole using tert-butyl chloroacetate followed by a non-aqueous ester cleavage of the resulting imidazol-1-yl-acetic acid tert-butyl ester in the presence of titanium tetrachloride. The synthesized imidazol-1-yl-acetic acid hydrochloride was then utilized to prepare zoledronic acid.

introduction: the purpose of this study was to investigate the effect of 6w power carbon dioxide laser (co2) on the biologic compatibility of the sandblasting with large grit and acid etching (sla) titanium discs through studying of the sarcoma osteogenic (saos-2) human osteoblast-like cells viability. methods: sterilized titanium discs were used together with saos-2 human osteoblast-like cells...

Titanium implants have a thin oxide surface layer. The properties of this oxide layer may explain the good biocompatibility of titanium implants. Anodic oxidation results in a thickening of the oxide film, with possible improved biocompatability of anodized implants. The aim of the present study was twofold: (1) firstly, to characterize the growth behaviour of galvanostatically prepared anodic ...

This study proposes a direct synthetic route to single titanate sheets through the mild and versatile conditions of the “chimie douce”. The stages of the production include the complexation of the titanium alkoxide precursor by benzoic acid, the formation of titanium oxo-clusters and their controlled transformation into single sheet titanates during the hydrolysis stage. The resulted material a...

Titanium dioxide nano-particles were synthesized via the sol-gel method using titanium butoxide as the precursor. Acid catalyzed and aged gels were dried under air to produce xerogels and under supercritical conditions to produce aerogels. Porous particles obtained were characterized using X-ray diffraction, SEM and BET analysis. Aerogel powder was found to have more favorable properties compar...

Titanium and its alloys present high interests for technological applications due to their high corrosion resistance, mechanical properties and biocompatibility. In combination with these remarkable characteristics, some Ti applications require specific surface properties that can be imparted with suitable surface functionalizations of the TiO(2) oxide layer. The present work aims to study the ...

Titanium dioxide nanocrystals were synthesized by sol-gel method at room temperature. Titanium isoprophoxide and absolute ethanol were used as precursors to prepare the sol. The pH of the solution was adjusted by adding nitric acid and sodium hydroxide solution. The prepared TiO2 nanocrystals were annealed at 325°C, 425°C and 525°C respectively. The effect of pH on the surface morphology and st...

ABSTRACT Mixed-metal oxo clusters Cu4Ti5O6(OOCR)16 (OOCR = methacrylate, propionate) were obtained by reaction of titanium alkoxides and copper carboxylates with propionic or methacrylic acid. GRAPHICAL ABSTRACT

This review covers several basic methodologies of surface treatment and their effects on titanium (Ti) implants. The importance of each treatment and its effects will be discussed in detail in order to compare their effectiveness in promoting osseointegration. Published literature for the last 18 years was selected with the use of keywords like titanium dental implant, surface roughness, coatin...

OBJECTIVES Acid etching is a popular method to texture the surface of dental implants. During etching, the titanium oxide protective layer is dissolved and small native hydrogen ions diffuse into the unprotected implant surface. They enrich the implant surface with hydrogen and precipitate into titanium hydride (TiH). The aim of this study was to measure the concentration of TiH at the implant ...