Quantitative second-harmonic generation imaging is employed to assess stromal collagen in normal, hyperplastic, dysplastic, and malignant breast tissues. The cellular scale organization is quantified using Fourier transform-second harmonic generation imaging (FT-SHG), while the molecular scale organization is quantified using polarization-resolved second-harmonic generation measurements (P-SHG)...

conclusions the tsi analysis in patients with cad may be considered an interesting parameter in addition to the conventional echocardiographic parameters during ese. background stress echocardiography represents one of the best possible imaging choice for the diagnosis and stratification of patients with coronary artery disease (cad). however, this imaging technique presents some limitations su...

Non-alcoholic steatohepatitis (NASH) is a common liver disorder caused by fatty liver. Because NASH is associated with fibrotic and morphological changes in liver tissue, a direct imaging technique is required for accurate staging of liver tissue. For this purpose, in this study we took advantage of two label-free optical imaging techniques, second harmonic generation (SHG) and auto-fluorescenc...

OBJECTIVE The purpose of this study was to evaluate different sonographic settings (tissue harmonic, frequency compounding, and conventional imaging) and to determine which setting optimizes breast lesion detection and lesion characterization. METHODS Four hundred thirteen consecutive breast lesions (249 benign and 164 malignant) were evaluated by sonography using 4 different modes (conventio...

An angular spectrum decomposition method (ASM) for calculating second-harmonic propagation in fluid-like media is discussed. This method is based on a perturbation solution of Westervelt’s equation, which can be augmented to take into account inhomogeneity of the medium. ASM can be applied to the analysis of tissue harmonic imaging (THI), a diagnostic method that utilizes second harmonics for i...

Several microbubble ultrasound contrast agents (UCA) have been recently introduced to allow imaging blood perfusion in the microvasculature. Microbubbles exhibit strong linear and nonlinear response to incident ultrasonic beams that can be utilized to increase the contrast-to-tissue ratio (CTR). If successful, this will lead to functional ultrasonic imaging methods. This increased interest in U...

In this paper, first the limitations of the ray-based method and the one-way wave-field extrapolation migration (WEM) in imaging steeply dipping structures are discussed by some examples. Then a new method of the reverse time migration (RTM), used in imaging such complex structures is presented. The proposed method uses a new wave-field extrapolator called the Leapfrog-Rapid Expansion Method (L...